Cold temperature can evoke a wide spectrum of perceptual sensations that range from
freshness to unpleasant cold or overt pain. In mammals, the detection of cold temperature is …

Sensations of cold are mediated by specific thermoreceptor nerve endings excited by low
temperature and menthol. Here we identify a population of cold-sensitive cultured mouse …

Cold temperature detection involves the process of sensory transduction in cutaneous
primary sensory nerve terminals, which converts thermal stimuli into depolarizations of the …

The detection of ambient cold is critical for mammals, who use this information to avoid
tissue damage by cold and to maintain stable body temperature. The transduction of …

Cutaneous thermosensation plays an important role in thermal regulation and detection of
potentially harmful thermal stimuli. Multiple classes of primary afferents are responsive to …

We feel a wide range of temperatures spanning from coldness to heat. Within this range,
temperatures over about 43 C and below about 15 C evoke not only a thermal sensation, but …

Our ability to perceive temperature is crucial: it enables us to swiftly react to noxiously cold or
hot objects and helps us to maintain a constant body temperature. Sensory nerve endings …

Three sub-populations of sensory neurons may be distinguished based on responses to a
decrease in temperature: one has a relatively low threshold for activation (cool fibers), a …

Of somatosensory modalities, cold is one of the more ambiguous percepts, evoking the
pleasant sensation of cooling, the stinging bite of cold pain, and welcome relief from chronic …

The abilities to sense environmental and internal temperatures are required for survival,
both for maintenance of homeostasis and for avoidance of tissue-damaging noxious …