Molecular mechanisms of amyloidosis
G Merlini, V Bellotti - New England Journal of Medicine, 2003 - Mass Medical Soc
Amyloidosis affects millions of people, as a cause of Alzheimer's disease or a complication
of dialysis, and also causes rare conditions. The many forms of the disorder have one …
of dialysis, and also causes rare conditions. The many forms of the disorder have one …
The systemic amyloidoses: clearer understanding of the molecular mechanisms offers hope for more effective therapies
G Merlini, P Westermark - Journal of internal medicine, 2004 - Wiley Online Library
Knowledge about the systemic amyloidoses has increased considerably during the last few
years. This group of diseases is characterized by great biochemical variability, including at …
years. This group of diseases is characterized by great biochemical variability, including at …
The amyloid phenomenon and its links with human disease
CM Dobson - Cold Spring Harbor perspectives in biology, 2017 - cshperspectives.cshlp.org
The ability of normally soluble proteins to convert into amyloid fibrils is now recognized to be
a generic phenomenon. The overall cross-β architecture of the core elements of such …
a generic phenomenon. The overall cross-β architecture of the core elements of such …
The genetics of the amyloidoses
JN Buxbaum, CE Tagoe - Annual review of medicine, 2000 - annualreviews.org
▪ Abstract The amyloidoses are diseases in which abnormalities in the secondary structure
of precursor proteins result in decreased solubility under physiologic conditions, with …
of precursor proteins result in decreased solubility under physiologic conditions, with …
Amyloidosis-associated kidney disease
LM Dember - Journal of the American Society of Nephrology, 2006 - journals.lww.com
The amyloidoses are a group of disorders in which soluble proteins aggregate and deposit
extracellularly in tissues as insoluble fibrils, causing progressive organ dysfunction. The …
extracellularly in tissues as insoluble fibrils, causing progressive organ dysfunction. The …
Genetic aspects of amyloidosis
DR Jacobson, JN Buxbaum - Advances in human genetics, 1991 - Springer
The amyloidoses are diseases characterized by the extracellular accumulation of insoluble
protein fibrils. From the initial pathologic description by Virchow in the mid-19th century until …
protein fibrils. From the initial pathologic description by Virchow in the mid-19th century until …
Systemic amyloidoses
LM Blancas-Mejía… - Annual review of …, 2013 - annualreviews.org
The amyloidoses are a group of protein misfolding diseases in which the precursor protein
undergoes a conformational change that triggers the formation of amyloid fibrils in different …
undergoes a conformational change that triggers the formation of amyloid fibrils in different …
How I treat amyloidosis: the importance of accurate diagnosis and amyloid typing
Amyloidosis is a rare group of diseases characterized by deposition of amyloid fibrils in soft
tissues. More than 28 types of amyloid have been identified. They all share common …
tissues. More than 28 types of amyloid have been identified. They all share common …
Cerebral amyloidosis: amyloid subunits, mutants and phenotypes
Cerebral amyloid diseases are part of a complex group of chronic and progressive entities
bracketed together under the common denomination of protein folding disorders and …
bracketed together under the common denomination of protein folding disorders and …
The workings of the amyloid diseases
V Bellotti, M Nuvolone, S Giorgetti, L Obici… - Annals of …, 2007 - Taylor & Francis
The amyloidoses constitute a large group of diseases caused by an alteration in the
conformation and metabolism of several globular proteins which, under particular …
conformation and metabolism of several globular proteins which, under particular …