Acute lymphoblastic leukemia (ALL) cells disrupt the healthy bone marrow
microenvironment to create a leukemic niche that is crucial for facilitating leukemogenesis …

Acute lymphoblastic leukemia (ALL) cells reside in the bone marrow microenvironment
which nurtures and protects cells from chemotherapeutic drugs. The disruption of cell-cell …

Simple Summary Tunneling nanotubes (TNTs) are cytoplasmic channels which regulate the
contacts between cells and allow the transfer of several elements, including ions …

Highlights•Hematopoietic progenitors are interconnected by F-actin-dependent TNTs.•Cell
dislodgement is the primary mechanism responsible for TNT biogenesis.•TNTs emerge from …

Acute myeloid leukemia (AML) is a bone marrow derived blood cancer where intercellular
communication in the leukemic bone marrow participates in disease development …

Intercellular communication within the bone marrow niche significantly promotes
leukemogenesis and provides protection of leukemic cells from therapy. Secreted factors …

Chronic myeloid leukemia (CML) is a stem cell disease of the bone marrow where
mechanisms of inter-leukemic communication and cell-to-cell interactions are proposed to …

Tunneling nanotubes (TNT) are dynamic connections between cells, which represent a
novel route for cell-to-cell communication. A growing body of evidence points TNT towards a …

Tunneling nanotubes (TnTs) are thin channels that temporally connect nearby cells allowing
the cell-to-cell trafficking of biomolecules and organelles. The presence or absence of TnTs …

Tunneling nanotubes (TNTs) are thin membrane tubes connecting remote cells and allowing
the transfer of cellular content. TNTs have been reported in several cancer in vitro, ex vivo …