Inflammasomes and their roles in health and disease

M Lamkanfi, VM Dixit - Annual review of cell and developmental …, 2012 - annualreviews.org
Inflammasomes are a set of intracellular protein complexes that enable autocatalytic
activation of inflammatory caspases, which drive host and immune responses by releasing …

Inflammasomes: mechanism of assembly, regulation and signalling

P Broz, VM Dixit - Nature Reviews Immunology, 2016 - nature.com
Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …

Deregulated inflammasome signaling in disease

M Lamkanfi, LV Walle, TD Kanneganti - Immunological reviews, 2011 - Wiley Online Library
Inflammasomes are multi‐protein complexes that sense microbial molecules and
endogenous danger signals in intracellular compartments. Inflammasome assembly results …

Inflammasomes: mechanisms of action and involvement in human diseases

D Bulté, C Rigamonti, A Romano, A Mortellaro - Cells, 2023 - mdpi.com
Inflammasome complexes and their integral receptor proteins have essential roles in
regulating the innate immune response and inflammation at the post-translational level. Yet …

Inflammasomes: mechanism of action, role in disease, and therapeutics

H Guo, JB Callaway, JPY Ting - Nature medicine, 2015 - nature.com
The inflammasomes are innate immune system receptors and sensors that regulate the
activation of caspase-1 and induce inflammation in response to infectious microbes and …

Molecular mechanisms involved in inflammasome activation

C Bryant, KA Fitzgerald - Trends in cell biology, 2009 - cell.com
Germline-encoded pattern recognition receptors (PRRs) sense microbial or endogenous
products released from damaged or dying cells and trigger innate immunity. In most cases …

Inflammasome activation and regulation: toward a better understanding of complex mechanisms

D Zheng, T Liwinski, E Elinav - Cell discovery, 2020 - nature.com
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Mechanisms of inflammasome activation: recent advances and novel insights

SK Vanaja, VAK Rathinam, KA Fitzgerald - Trends in cell biology, 2015 - cell.com
Inflammasomes are cytosolic multiprotein platforms assembled in response to invading
pathogens and other danger signals. Typically inflammasome complexes contain a sensor …

Inflammasome biology, molecular pathology and therapeutic implications

F Awad, E Assrawi, C Louvrier, C Jumeau… - Pharmacology & …, 2018 - Elsevier
Inflammasomes are intracellular multiprotein signaling complexes, mainly present in
myeloid cells. They commonly assemble around a cytoplasmic receptor of the nucleotide …

Inflammasomes as therapeutic targets in human diseases

Y Li, H Huang, B Liu, Y Zhang, X Pan, XY Yu… - Signal transduction and …, 2021 - nature.com
Inflammasomes are protein complexes of the innate immune system that initiate
inflammation in response to either exogenous pathogens or endogenous danger signals …