Background—Marfan syndrome (MFS) is caused by mutations in the fibrillin-1 gene and
dysregulation of transforming growth factor-β (TGF-β). Recent evidence suggests that …

Background Marfan syndrome (MFS) is caused by mutations in the gene encoding fibrillin‐1
(FBN 1); however, the mechanisms through which fibrillin‐1 deficiency causes MFS …

Abstract Background Patients with Marfan syndrome (MFS) are at risk for cardiovascular
disease. Marfan associated mutations in the FBN1 gene lead to increased transforming …

OBJECTIVE: Marfan syndrome is a systemic connective tissue disorder caused by mutations
in the fibrillin-1 gene. It was originally believed that Marfan syndrome results exclusively …

Background—It has been shown that losartan reduces aortic dilatation in patients with
Marfan syndrome. However, treatment response is highly variable. This study investigates …

Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder
caused by mutations in the gene that encodes fibrillin-1. Selected manifestations of MFS …

Marfan syndrome is a common inherited disorder of connective tissue caused by deficiency
of the matrix protein fibrillin-1. Effective surgical therapy for the most life-threatening …

Marfan syndrome (MFS) is an autosomal dominant heritable disorder of connective tissue
that affects the cardiovascular, skeletal, ocular, pulmonary, and nervous systems and is …

Background—TGFBR2 mutations were recognized recently among patients with a Marfan-
like phenotype. The associated clinical and prognostic spectra remain unclear. Methods and …

Marfan syndrome is an autosomal dominant connective tissue disease with an estimated
incidence of 1 in 5000 individuals. In 90% of cases it is caused by mutations in the gene for …