Altered calcium handling and ventricular arrhythmias in acute ischemia

P Baumeister, TA Quinn - Clinical Medicine Insights …, 2016 - journals.sagepub.com
Acute ischemia results in deadly cardiac arrhythmias that are a major contributor to sudden
cardiac death (SCD). The electrophysiological changes involved have been extensively …

Mechanisms and potential therapeutic targets for ventricular arrhythmias associated with impaired cardiac calcium cycling

KR Laurita, DS Rosenbaum - Journal of molecular and cellular cardiology, 2008 - Elsevier
The close relationship between life-threatening ventricular arrhythmias and contractile
dysfunction in the heart implicates intracellular calcium cycling as an important underlying …

Calcium dynamics and cardiac arrhythmia

M Deo, SH Weinberg, PM Boyle - Clinical Medicine Insights …, 2017 - journals.sagepub.com
This Special Collection will gather all studies highlighting recent advances in theoretical and
experimental studies of arrhythmia, with a specific focus on research seeking to elucidate …

Ca2+ Sparks and Ca2+ waves are the subcellular events underlying Ca2+ overload during ischemia and reperfusion in perfused intact hearts

A Mattiazzi, M Argenziano, Y Aguilar-Sanchez… - Journal of Molecular and …, 2015 - Elsevier
Abnormal intracellular Ca 2+ cycling plays a key role in cardiac dysfunction, particularly
during the setting of ischemia/reperfusion (I/R). During ischemia, there is an increase in …

Mechanisms of sudden cardiac death

M Rubart, DP Zipes - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
Despite recent advances in preventing sudden cardiac death (SCD) due to cardiac
arrhythmia, its incidence in the population at large has remained unacceptably high. Better …

Towards an integrated understanding of cardiac arrhythmogenesis− Growing roles of experimental pathology

H Tanaka, T Matsuyama… - Pathology International, 2017 - Wiley Online Library
Cardiac arrhythmias have long been regarded as derangement of electrical impulse
initiation and conduction within the heart. However, underlying mechanisms for …

Role of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death

S Wagner, LS Maier, DM Bers - Circulation research, 2015 - Am Heart Assoc
Despite improvements in the therapy of underlying heart disease, sudden cardiac death is a
major cause of death worldwide. Disturbed Na and Ca handling is known to be a major …

Regulation of ion channels and arrhythmias in the ischemic heart

JG Akar, FG Akar - Journal of electrocardiology, 2007 - Elsevier
Ventricular arrhythmias in the setting of ischemic heart disease is a leading cause of
mortality in the United States. A better understanding of the complex changes associated …

Arrhythmogenic substrates in myocardial infarct

T Takamatsu - Pathology international, 2008 - Wiley Online Library
Life‐threatening ventricular tachyarrhythmias are common clinical complications in ischemic
heart diseases, especially infarcted heart. Although electrophysiological mechanisms have …

[引用][C] Calcium overload, spontaneous calcium release, and ventricular arrhythmias

KR Sipido - Heart rhythm, 2006 - heartrhythmjournal.com
The link between calcium (Ca2+) and arrhythmias goes back to the early days of
electrophysiology and calcium measurements. This viewpoint highlights some of the new …