A major challenge in tuberculosis (TB) is to improve current vaccination and therapeutic
strategies and this requires a fine understanding of the mechanisms that mediate protection …

Tuberculosis (TB) remains a serious global public health problem that results in up to 2
million deaths each year. TB is caused by the human pathogen, Mycobacterium tuberculosis …

The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Tuberculosis is still a major health problem in the world. Initial interactions between
Mycobacterium tuberculosis and the host mark the pathway of infection and the subsequent …

Macrophages are first-line responders against microbes. The success of Mycobacterium
tuberculosis (Mtb) rests upon its ability to convert these antimicrobial cells into a permissive …

Infection with Mycobacterium tuberculosis (MTB) is accompanied by an intense local
inflammatory response which may be critical to the pathogenesis of tuberculosis. Activation …

Tuberculosis (TB) is the outcome of an insidious, protracted infection with Mycobacterium
tuberculosis (Mtb). It primarily affects the lung and is characterized by extensive focal …

As the first line of immune defense for Mycobacterium tuberculosis (Mtb), macrophages also
provide a major habitat for Mtb to reside in the host for years. The battles between Mtb and …

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …