The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle
ER Flores, BL Allen-Hoffmann, D Lee… - Journal of …, 2000 - Am Soc Microbiol
The production of the human papillomavirus type 16 (HPV-16) is intimately tied to the
differentiation of the host epithelium that it infects. Infection occurs in the basal layer of the …
differentiation of the host epithelium that it infects. Infection occurs in the basal layer of the …
Human papillomavirus type 31 E5 protein supports cell cycle progression and activates late viral functions upon epithelial differentiation
F Fehrmann, DJ Klumpp, LA Laimins - Journal of virology, 2003 - Am Soc Microbiol
The function of the E5 protein of human papillomaviruses (HPV) is not well characterized,
and controversies exist about its role in the viral life cycle. To determine the function of E5 …
and controversies exist about its role in the viral life cycle. To determine the function of E5 …
Quantitative role of the human papillomavirus type 16 E5 gene during the productive stage of the viral life cycle
SM Genther, S Sterling, S Duensing… - Journal of …, 2003 - Am Soc Microbiol
Human papillomaviruses (HPVs) are small circular DNA viruses that cause warts. Infection
with high-risk anogenital HPVs, such as HPV type 16 (HPV16), is associated with human …
with high-risk anogenital HPVs, such as HPV type 16 (HPV16), is associated with human …
Role of the E1∧E4 Protein in the Differentiation-Dependent Life Cycle of Human Papillomavirus Type 31
R Wilson, F Fehrmann, LA Laimins - Journal of virology, 2005 - Am Soc Microbiol
The most highly expressed protein in the productive life cycle of human papillomaviruses
(HPVs) is E1∧ E4, but its function is not well understood. To investigate the role of E1∧ E4 …
(HPVs) is E1∧ E4, but its function is not well understood. To investigate the role of E1∧ E4 …
The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in …
SA Sedman, MS Barbosa, WC Vass… - Journal of …, 1991 - Am Soc Microbiol
The wild-type E6 and E7 genes of human papillomavirus type 16 (HPV16) can cooperate to
immortalize normal human keratinocytes in culture. The E6 open reading frame of HPV16 …
immortalize normal human keratinocytes in culture. The E6 open reading frame of HPV16 …
[HTML][HTML] The full-length E1^ E4 protein of human papillomavirus type 18 modulates differentiation-dependent viral DNA amplification and late gene expression
Activation of the productive phase of the human papillomavirus (HPV) life cycle in
differentiated keratinocytes is coincident with high-level expression of E1^ E4 protein. To …
differentiated keratinocytes is coincident with high-level expression of E1^ E4 protein. To …
The E8^ E2C protein, a negative regulator of viral transcription and replication, is required for extrachromosomal maintenance of human papillomavirus type 31 in …
The viral E2 protein is a major regulator of papillomavirus DNA replication. An important way
to influence viral replication is through modulation of the activity of the E2 protein. This could …
to influence viral replication is through modulation of the activity of the E2 protein. This could …
The viral E8^ E2C repressor limits productive replication of human papillomavirus 16
E Straub, M Dreer, J Fertey, T Iftner… - Journal of …, 2014 - Am Soc Microbiol
Productive replication of human papillomavirus type 16 (HPV16) occurs only in differentiated
keratinocyte cells. In addition to the viral E2 activator protein, HPV16 and related HPV types …
keratinocyte cells. In addition to the viral E2 activator protein, HPV16 and related HPV types …
Biological activities and molecular targets of the human papillomavirus E7 oncoprotein
K Münger, JR Basile, S Duensing, A Eichten… - Oncogene, 2001 - nature.com
The human papillomavirus (HPV) E7 protein is one of only two viral proteins that remain
expressed in HPV-associated human cancers. HPV E7 proteins share structural and …
expressed in HPV-associated human cancers. HPV E7 proteins share structural and …
Transactivation by the E2 protein of oncogenic human papillomavirus type 31 is not essential for early and late viral functions
F Stubenrauch, AME Colbert, LA Laimins - Journal of virology, 1998 - Am Soc Microbiol
The activation of transcription and of DNA replication are, in some cases, mediated by the
same proteins. A prime example is the E2 protein of human papillomaviruses (HPVs), which …
same proteins. A prime example is the E2 protein of human papillomaviruses (HPVs), which …