Targeting T cell (oxidative) metabolism to improve immunity to viral infection in the context of obesity
E Greene, NJ MacIver - Frontiers in Immunology, 2022 - frontiersin.org
Disorders of systemic metabolism can influence immunity. Individuals with obesity are
known to have increased inflammation, increased risk to select autoimmune diseases …
known to have increased inflammation, increased risk to select autoimmune diseases …
Obesity altered T cell metabolism and the response to infection
WD Green, MA Beck - Current opinion in immunology, 2017 - Elsevier
Highlights•Obesity impairs immune response through altered T cell activation and
function.•Obese adipocytes promote pro-inflammatory milieu altering T cell …
function.•Obese adipocytes promote pro-inflammatory milieu altering T cell …
Targeting T-cell oxidative metabolism to improve influenza survival in a mouse model of obesity
Y Alwarawrah, AG Nichols, WD Green… - International Journal of …, 2020 - nature.com
Background Obesity is associated with impaired primary and secondary immune responses
to influenza infection, with T cells playing a critical role. T-cell function is highly influenced by …
to influenza infection, with T cells playing a critical role. T-cell function is highly influenced by …
Obesity dysregulates the immune response to influenza infection and vaccination through metabolic and inflammatory mechanisms
SR Shaikh, NJ MacIver, MA Beck - Annual review of nutrition, 2022 - annualreviews.org
The COVID-19 pandemic demonstrates that obesity alone, independent of comorbidities, is
a significant risk factor for severe outcomes from infection. This susceptibility mirrors a …
a significant risk factor for severe outcomes from infection. This susceptibility mirrors a …
Impact of obesity and SARS-CoV-2 infection: implications for host defence-a living review
FC Richter, A Alrubayyi, A Teijeira Crespo… - Oxford Open …, 2021 - academic.oup.com
The role of obesity in the pathophysiology of respiratory virus infections has become
particularly apparent during the current severe acute respiratory syndrome coronavirus 2 …
particularly apparent during the current severe acute respiratory syndrome coronavirus 2 …
Dysregulated inflammation during obesity: driving disease severity in influenza virus and SARS-CoV-2 infections
Acute inflammation is a critical host defense response during viral infection. When
dysregulated, inflammation drives immunopathology and tissue damage. Excessive …
dysregulated, inflammation drives immunopathology and tissue damage. Excessive …
The role of obesity in the immunopathogenesis of COVID-19 respiratory disease and critical illness
SJ Kuperberg, B Navetta-Modrov - American journal of respiratory …, 2021 - atsjournals.org
Coronavirus disease (COVID-19), the clinical syndrome caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is currently a global health pandemic with …
syndrome coronavirus 2 (SARS-CoV-2), is currently a global health pandemic with …
The collision of meta-inflammation and SARS-CoV-2 pandemic infection
Abstract The coronavirus disease 2019 (COVID-19) pandemic has forced us to consider the
physiologic role of obesity in the response to infectious disease. There are significant …
physiologic role of obesity in the response to infectious disease. There are significant …
Obesity, COVID-19 and innate immunometabolism
As COVID-19 continues to spread worldwide, severe disease and mortality have been
observed in obese patients. We discuss how obesity and obesity-associated factors such as …
observed in obese patients. We discuss how obesity and obesity-associated factors such as …
Immunometabolic Dysregulation at the Intersection of Obesity and COVID-19
Obesity prevails worldwide to an increasing effect. For example, up to 42% of American
adults are considered obese. Obese individuals are prone to a variety of complications of …
adults are considered obese. Obese individuals are prone to a variety of complications of …