Immune senescence, immunosenescence and aging
With aging, there is increased dysfunction of both innate and adaptive immune responses,
which contributes to impaired immune responses to pathogens and greater mortality and …
which contributes to impaired immune responses to pathogens and greater mortality and …
The twilight of the immune system: The impact of immunosenescence in aging
Cellular senescence is a critical part of human anti-tumor defence; however, the
accumulation of senescent cells with age underpins a wide range of pathologies. Senescent …
accumulation of senescent cells with age underpins a wide range of pathologies. Senescent …
Immunosenescence: molecular mechanisms and diseases
Z Liu, Q Liang, Y Ren, C Guo, X Ge, L Wang… - Signal transduction and …, 2023 - nature.com
Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …
Immune system modulation in aging: Molecular mechanisms and therapeutic targets
B Cisneros, I García-Aguirre, J Unzueta… - Frontiers in …, 2022 - frontiersin.org
The function of the immune system declines during aging, compromising its response
against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the …
against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the …
Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells
D Zhou, M Borsa, AK Simon - Aging Cell, 2021 - Wiley Online Library
The ageing of the global population brings about unprecedented challenges. Chronic age‐
related diseases in an increasing number of people represent an enormous burden for …
related diseases in an increasing number of people represent an enormous burden for …
Aging and chronic inflammation: highlights from a multidisciplinary workshop
D Saavedra, AL Añé-Kourí, N Barzilai, C Caruso… - Immunity & …, 2023 - Springer
Aging is a gradual, continuous series of natural changes in biological, physiological,
immunological, environmental, psychological, behavioral, and social processes. Aging …
immunological, environmental, psychological, behavioral, and social processes. Aging …
The untwining of immunosenescence and aging
From a holistic point of view, aging results from the cumulative erosion of the various
systems. Among these, the immune system is interconnected to the rest as immune cells are …
systems. Among these, the immune system is interconnected to the rest as immune cells are …
[HTML][HTML] Cellular senescence in lymphoid organs and immunosenescence
V Budamagunta, TC Foster, D Zhou - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Immunosenescence is a multi-faceted phenomenon at the root of age-associated immune
dysfunction. It can lead to an array of pathological conditions, including but not limited to a …
dysfunction. It can lead to an array of pathological conditions, including but not limited to a …
Aging and options to halt declining immunity to virus infections
MÁ Palacios-Pedrero, ADME Osterhaus… - Frontiers in …, 2021 - frontiersin.org
Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …
Paradoxical changes in innate immunity in aging: recent progress and new directions
RR Montgomery, AC Shaw - Journal of Leucocyte Biology, 2015 - academic.oup.com
Immunosenescence, describing alterations, including decline of immune responses with
age, is comprised of inappropriate elevations, decreases, and dysregulated immune …
age, is comprised of inappropriate elevations, decreases, and dysregulated immune …