Quantifying the optimal structure of the autism phenotype: A comprehensive comparison of dimensional, categorical, and hybrid models

H Kim, C Keifer, C Rodriguez-Seijas, N Eaton… - Journal of the American …, 2019 - Elsevier
Objective The two primary—seemingly contradictory—strategies for classifying child
psychiatric syndromes are categorical and dimensional; conceptual ambiguities appear to …

Autism spectrum disorders as a qualitatively distinct category from typical behavior in a large, clinically ascertained sample

TW Frazier, EA Youngstrom, L Sinclair… - …, 2010 - journals.sagepub.com
The present study evaluated the hypothesis that autism spectrum disorders (ASDs) are best
represented as a discrete category distinct from typical behavior within autism-affected …

A cluster analysis exploration of autism spectrum disorder subgroups in children without intellectual disability

F Klopper, R Testa, C Pantelis, E Skafidas - Research in Autism Spectrum …, 2017 - Elsevier
Background The heterogeneity in autism spectrum disorder (ASD) remains poorly
understood, particularly in individuals without intellectual disability (ID), where phenotypic …

Multidimensional influences on autism symptom measures: implications for use in etiological research

KA Havdahl, VH Bal, M Huerta, A Pickles… - Journal of the American …, 2016 - Elsevier
Objective Growing awareness that symptoms of autism spectrum disorder (ASD) transcend
multiple diagnostic categories, and major advances in the identification of genetic …

Variation in the early trajectories of autism symptoms is related to the development of language, cognition, and behavior problems

JC Visser, NNJ Rommelse, M Lappenschaar… - Journal of the American …, 2017 - Elsevier
Objective The objectives of this study were to model more homogeneous subgroups within
autism spectrum disorder (ASD) based on early trajectories of core symptoms; and to further …

A transdiagnostic model of psychiatric symptom co‐occurrence and autism spectrum disorder

C Rodriguez‐Seijas, KD Gadow, TE Rosen… - Autism …, 2020 - Wiley Online Library
Understanding whether the co‐occurrence of psychiatric symptoms within autism spectrum
disorder (ASD) are specific to the ASD diagnosis or reflect similar higher‐order patterns …

[HTML][HTML] Conceptualization of the latent structure of autism: further evidence and discussion of dimensional and hybrid models

S Wittkopf, A Langmann, V Roessner, S Roepke… - European Child & …, 2023 - Springer
Autism spectrum disorder (ASD) might be conceptualized as an essentially dimensional,
categorical, or hybrid model. Yet, current empirical studies are inconclusive and the latent …

From pattern classification to stratification: towards conceptualizing the heterogeneity of Autism Spectrum Disorder

T Wolfers, DL Floris, R Dinga, D van Rooij… - Neuroscience & …, 2019 - Elsevier
Pattern classification and stratification approaches have increasingly been used in research
on Autism Spectrum Disorder (ASD) over the last ten years with the goal of translation …

Re-conceptualizing ASD within a dimensional framework: Positive, negative, and cognitive feature clusters

JH Foss-Feig, JC McPartland, A Anticevic… - Journal of autism and …, 2016 - Springer
Abstract Introduction of the National Institute of Mental Health's Research Domain Criteria
and revision of diagnostic classification for Autism Spectrum Disorder in the latest diagnostic …

Classifying autism spectrum disorders by ADI-R: subtypes or severity gradient?

H Cholemkery, J Medda, T Lempp… - Journal of autism and …, 2016 - Springer
To reduce phenotypic heterogeneity of Autism spectrum disorders (ASD) and add to the
current diagnostic discussion this study aimed at identifying clinically meaningful ASD …