A single, subcutaneous, 30-g dose of either a combination of the Yersinia pestis proteins
F1V or a F1-V fusion protein adsorbed to the adjuvant aluminum hydroxide, protected Hsd …

Inhalation of Yersinia pestis bacilli causes pneumonic plague, a rapidly progressing and
exceptionally virulent disease. Extensively antibiotic-resistant Y. pestis strains exist and we …

Pneumonic plague, an often-fatal disease for which no vaccine is presently available, results
from pulmonary infection by the bacterium Yersinia pestis. The Y. pestis V protein is a …

To evaluate the role of Yersinia outer proteins (Yops) in conferring protective immunity
against plague, six yop loci from Yersinia pestis were individually amplified by PCR, cloned …

Yersinia pestis, the plague pathogen, is a facultative intracellular bacterium. Cellular
immunity plays important roles in defense against infections. The identification of T-cell …

Pulmonary infection with the bacterium Yersinia pestis causes pneumonic plague, an often-
fatal disease for which no vaccine is presently available. Antibody-mediated humoral …

The lpxM mutant of the live vaccine Yersinia pestis EV NIIEG strain synthesising a less toxic
penta-acylated lipopolysaccharide was found to be avirulent in mice and guinea pigs …

The fraction 1 capsular protein (F1) is considered an important but not essential virulence
factor unique to Y. pestis (Welkos et al., 1995). Immunization with the F1 protein has been …

The median lethal dose (MLD) of a pathogenic strain of Yersinia pestis was established by
three routes of administration in three strains of mouse. There was no significant difference …

Yersinia pestis causes bubonic and pneumonic plague in humans. The pneumonic infection
is the most severe and invariably fatal if untreated. Because of its high virulence, ease of …