Yersinia pestis, the agent of plague, is among the deadliest bacterial pathogens affecting
humans, and is a potential biological weapon. Because antibiotic resistant strains of …

In this study, a novel recombinant attenuated Yersinia pseudotuberculosis PB1+ strain
(χ10069) engineered with Δ yopK Δ yopJ Δ asd triple mutations was used to deliver a Y …

To develop a safe and effective live plague vaccine, the ΔyscB mutant was constructed
based on Yersinia pestis biovar Microtus strain 201 that is avirulent to humans, but virulent …

Vaccinating with live, conditionally attenuated, pigmentation (Pgm)-deficient Yersinia pestis
primes T cells that protect mice against pneumonic plague. However, Pgm-deficient strains …

Plague caused by Yersinia pestis manifests itself in bubonic, septicemic, and pneumonic
forms. Although the US Food and Drug Administration recently approved levofloxacin, there …

ABSTRACT A Yersinia pestis-derived fusion protein (F1-V) has shown great promise as a
protective antigen against aerosol challenge with Y. pestis in murine studies. In the current …

The potential application of Yersinia pestis for bioterrorism emphasizes the urgent need to
develop more effective vaccines against airborne infection. The current status of plague …

The ppGpp molecule is part of a highly conserved regulatory system for mediating the
growth response to various environmental conditions. This mechanism may represent a …

Yersinia pestis (YP) is the Gram-negative etiological agent of plague against which no
commercial vaccine exists to prophylactically prevent a potential outbreak due to natural or …

In this paper, we describe for the first time the use of a fully recombinant sub-unit vaccine for
plague. We have compared the protection afforded by the recombinant vaccine against …