The use of a DNA immunization approach to deliver protective antigens against Yersinia
pestis (Y. pestis) has been successful in previously reported studies. In the current study, the …

Plague is one of the world's most lethal human diseases caused by Yersinia pestis, a Gram-
negative bacterium. Despite overwhelming studies for many years worldwide, there is no …

Yersinia pestis is the causative agent of bubonic and pneumonic plague, human diseases
with high mortality. Due to the microbe's ability to spread rapidly, plague epidemics present …

Yersinia pestis is a dangerous bacterial pathogen that when inhaled can rapidly induce fatal
pneumonic plague. Thus, there is a need for stable, safe, and easily administered mucosal …

Pulmonary infection by Yersinia pestis causes pneumonic plague, a rapidly progressing and
often fatal disease. To aid the development of safe and effective pneumonic plague …

Background Plague is still a public health problem in the world and is re-emerging, but no
efficient vaccine is available. We previously reported that oral inoculation of a live attenuated …

Yersinia pestis biovar Microtus is considered to be a virulent to larger mammals, including
guinea pigs, rabbits and humans. It may be used as live attenuated plague vaccine …

Previously, we showed that deletion of genes encoding Braun lipoprotein (Lpp) and MsbB
attenuated Yersinia pestis CO92 in mouse and rat models of bubonic and pneumonic …

Despite many decades of intensive studies of Yersinia pestis, the causative agent of plague,
there is no safe and efficient vaccine against this devastating disease. A recently developed …

Yersinia pestis, the causative agent of plague, has been well studied at the molecular and
genetic levels, but little is known about the role that host genes play in combating this highly …