Irregular high frequency patterns decrease the effectiveness of deep brain stimulation in a rat model of Parkinson's disease

RQ So, GC McConnell, JD Hilliard… - 2011 5th International …, 2011 - ieeexplore.ieee.org
Deep brain stimulation (DBS) is an effective treatment of Parkinson's disease, but its
mechanisms are still unclear. To test the hypothesis that DBS alleviates motor symptoms by …

Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease

DT Brocker, BD Swan, DA Turner, RE Gross… - Experimental …, 2013 - Elsevier
High frequency deep brain stimulation is an effective therapy for motor symptoms in
Parkinson's disease. However, the relative clinical efficacy of regular versus non-regular …

Patterned low-frequency deep brain stimulation induces motor deficits and modulates cortex-basal ganglia neural activity in healthy rats

CS Oza, DT Brocker, CE Behrend… - Journal of …, 2018 - journals.physiology.org
Deep brain stimulation (DBS) is an effective therapy for movement disorders, including
Parkinson's disease (PD), although the mechanisms of action remain unclear. Abnormal …

Effective deep brain stimulation suppresses low-frequency network oscillations in the basal ganglia by regularizing neural firing patterns

GC McConnell, RQ So, JD Hilliard… - Journal of …, 2012 - Soc Neuroscience
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for
the motor symptoms of Parkinson's disease (PD). The effects of DBS depend strongly on …

Multiple stimulation parameters influence efficacy of deep brain stimulation in parkinsonian mice

JS Schor, AB Nelson - The Journal of clinical investigation, 2019 - Am Soc Clin Investig
Deep brain stimulation (DBS) is used to treat multiple neuropsychiatric disorders, including
Parkinson's disease (PD). Despite widespread clinical use, its therapeutic mechanisms are …

Theta-phase closed-loop stimulation induces motor paradoxical responses in the rat model of Parkinson disease

I Cordon, MJ Nicolás, S Arrieta, M Alegre, J Artieda… - Brain stimulation, 2018 - Elsevier
Background High-frequency deep brain stimulation (DBS) has become a widespread
therapy used in the treatment of Parkinson's Disease (PD) and other diseases. Although it …

Failure to suppress low-frequency neuronal oscillatory activity underlies the reduced effectiveness of random patterns of deep brain stimulation

GC McConnell, RQ So, WM Grill - Journal of …, 2016 - journals.physiology.org
Subthalamic nucleus (STN) deep brain stimulation (DBS) is an established treatment for the
motor symptoms of Parkinson's disease (PD). However, the mechanisms of action of DBS …

Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation

S Li, GW Arbuthnott, MJ Jutras… - Journal of …, 2007 - journals.physiology.org
Deep brain stimulation (DBS) is an effective treatment of Parkinson's disease (PD) for many
patients. The most effective stimulation consists of high-frequency biphasic stimulation …

Deep brain stimulation in Parkinson's disease can mimic the 300 Hz subthalamic rhythm

G Foffani, A Priori - Brain, 2006 - academic.oup.com
We read with much interest the paper by Meissner et al.(2005) recently published in Brain.
The authors provided neurophysiological evidence that in MPTP-treated monkeys high …

A perspective on the use of high-frequency stimulation in deep brain stimulation for Parkinson's disease

VV Shah, S Goyal… - 2016 Indian Control …, 2016 - ieeexplore.ieee.org
Parkinson's disease is a neurodegenerative disorder of the central nervous system and
among the symptoms, rest tremors is one of the key symptoms. Deep Brain Stimulation …