Neurodegeneration, the slow and progressive dysfunction and loss of neurons and axons in
the central nervous system, is the primary pathological feature of acute and chronic …

Multiple sclerosis is a neurologic disease caused by immune cell infiltration into the central
nervous system, resulting in gray and white matter inflammation, progressive demyelination …

Alzheimer's disease patients display neuropathological lesions, including the accumulation
of amyloid-beta (Aβ) peptide and neurofibrillary tangles. Although the mechanisms causing …

Glaucoma is a group of optic neuropathies characterized by the degeneration of retinal
ganglion cell axons and somas, ultimately preventing light signals in the retina from …

The dysregulation of inflammatory responses and of immune self-tolerance is considered to
be a key element in the autoreactive immune response in multiple sclerosis (MS) …

Neuroinflammation constitutes a fundamental cellular process to signal the loss of brain
homeostasis. Glial cells play a central role in orchestrating these neuroinflammation …

Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key
signaling steps of innate immune activation hence represent promising therapeutic targets …

Neuroinflammation is a complex integration of the responses of all cells present within the
CNS, including the neurons, macroglia, microglia and the infiltrating leukocytes. The …

Abstract CD4+ CD25+ Foxp3+ Regulatory T cells (Tregs) play a critical role in immune
tolerance. The plasticity and functional adaptability of Tregs in an inflammatory …

Experimental autoimmune uveitis (EAU) in animals serves as a model of human uveitis.
EAU can be induced in mice by immunization with the retinal antigen interphotoreceptor …