Cis-acting regulatory sequence elements are sequences contained in the 30 and 50
untranslated region, introns, or coding regions of precursor RNAs and mature mRNAs that …

The regulation of gene expression is a fundamental cellular process that is controlled at
multiple levels. Abnormal regulation of gene expression has been directly implicated in the …

GU-rich elements found in pre-mRNA and mRNA transcripts play diverse roles in the control
of gene expression by regulating mRNA stability, translation, and pre-mRNA processing …

A considerable number of genes that code for AU-rich mRNAs including cytokines, growth
factors, transcriptional factors, and certain receptors are involved in both chronic …

The metabolic lifetime of mRNA can be specified by specific cis-acting elements within
mRNA. One type of element is an adenylate-and uridylate-rich element (ARE) found in the …

Over the years, advancements in modern molecular biology have shed light on the complex
roles of RNA molecules. It is now well established that RNAs serve as more than just …

The process of protein synthesis (mRNA translation) is essential for the growth and survival
of all living organisms. Protein synthesis places heavy demands upon the cell—it requires a …

The expression of many proto-oncogenes, nuclear transcription factors and cytokines is
regulated post-transcriptionally by specific interactions between distinct cis-elements within …

Regulatory RNAs play an intrinsic part in the effective maintenance and preservation of our
genetic integrity. In this article, we summarize the rapidly advancing field of regulatory RNAs …

During recent years, it has become clear that regulation of mRNA stability is an important
event in the control of gene expression. The stability of a large class of mammalian mRNAs …