VEGF inhibition, hypertension, and renal toxicity
The use of anti-angiogenic agents as part of the therapeutic armamentarium for advanced
stage solid tumors has become the standard of care in several instances, particularly for …
stage solid tumors has become the standard of care in several instances, particularly for …
Hypertension and proteinuria: a class-effect of antiangiogenic therapies
V Launay-Vacher, G Deray - Anti-cancer drugs, 2009 - journals.lww.com
Antiangiogenic therapy has now become a cornerstone in the treatment of several solid
tumor cancers. Those drugs present with a renal toxicity profile manifesting as proteinuria …
tumor cancers. Those drugs present with a renal toxicity profile manifesting as proteinuria …
Renal effects of anti-angiogenesis therapy: update for the internist
F Gurevich, MA Perazella - The American journal of medicine, 2009 - Elsevier
Angiogenesis has become an innovative target in cancer therapy. Agents that inhibit
vascular endothelial growth factor (VEGF), one of the most potent promoters of …
vascular endothelial growth factor (VEGF), one of the most potent promoters of …
Vascular endothelial growth factor (VEGF) and VEGF receptor inhibitors in the treatment of renal cell carcinomas
R Roskoski Jr - Pharmacological Research, 2017 - Elsevier
Abstract One Von Hippel-Lindau (VHL) tumor suppressor gene is lost in most renal cell
carcinomas while the nondeleted allele exhibits hypermethylation-induced inactivation or …
carcinomas while the nondeleted allele exhibits hypermethylation-induced inactivation or …
Adverse effects of anticancer agents that target the VEGF pathway
HX Chen, JN Cleck - Nature reviews Clinical oncology, 2009 - nature.com
Antiangiogenesis agents that target the VEGF/VEGF receptor pathway have become an
important part of standard therapy in multiple cancer indications. With expanded clinical …
important part of standard therapy in multiple cancer indications. With expanded clinical …
Clinicopathological spectrum of kidney diseases in cancer patients treated with vascular endothelial growth factor inhibitors: a report of 5 cases and review of literature
J Usui, IG Glezerman, SP Salvatore, CB Chandran… - Human pathology, 2014 - Elsevier
Recently, cancer therapies have been supplemented by vascular endothelial growth factor
(VEGF) inhibitors as anti-angiogenic agents. However, kidney-related adverse reactions …
(VEGF) inhibitors as anti-angiogenic agents. However, kidney-related adverse reactions …
[引用][C] Hypertension, proteinuria, and antagonism of vascular endothelial growth factor signaling: clinical toxicity, therapeutic target, or novel biomarker?
WJ van Heeckeren, J Ortiz, MM Cooney… - Journal of Clinical …, 2007 - ascopubs.org
There are three US Food and Drug Administration–approved angiogenesis inhibitors for the
treatment of cancer that specifically target vascular endothelial growth factor (VEGF) …
treatment of cancer that specifically target vascular endothelial growth factor (VEGF) …
Clinical risk factors for the development of hypertension in patients treated with inhibitors of the VEGF signaling pathway
BACKGROUND VEGF signaling pathway inhibitor (anti‐VEGF) therapy is associated with
hypertension, but little is known about predisposing clinical characteristics. This study …
hypertension, but little is known about predisposing clinical characteristics. This study …
Bevacizumab-induced hypertension: pathogenesis and management
KN Syrigos, E Karapanagiotou, P Boura, C Manegold… - BioDrugs, 2011 - Springer
Bevacizumab, a recombinant humanized monoclonal antibody targeting the vascular
endothelial growth factor (VEGF), has been approved in the US as first-and second-line …
endothelial growth factor (VEGF), has been approved in the US as first-and second-line …
Vascular endothelial growth factor–targeted therapy in renal cell carcinoma: current status and future directions
BI Rini - Clinical Cancer Research, 2007 - AACR
Renal cell carcinoma is a highly vascular tumor associated with expression of vascular
endothelial growth factor (VEGF). Recently, VEGF-targeted therapies have been identified …
endothelial growth factor (VEGF). Recently, VEGF-targeted therapies have been identified …