[HTML][HTML] Joint GWAS analysis: comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases
MJ McGeachie, GL Clemmer, J Lasky-Su, A Dahlin… - Genomics data, 2014 - Elsevier
We show here that combining two existing genome wide association studies (GWAS) yields
additional biologically relevant information, beyond that obtained by either GWAS …
additional biologically relevant information, beyond that obtained by either GWAS …
Gene and pathway-based analysis: second wave of genome-wide association studies
Despite great success of GWAS in identification of common genetic variants associated with
complex diseases, the current GWAS have focused on single SNP analysis. However, single …
complex diseases, the current GWAS have focused on single SNP analysis. However, single …
Large scale analysis of phenotype-pathway relationships based on GWAS results
A Brodie, O Tovia-Brodie, Y Ofran - PloS one, 2014 - journals.plos.org
The widely used pathway-based approach for interpreting Genome Wide Association
Studies (GWAS), assumes that since function is executed through the interactions of multiple …
Studies (GWAS), assumes that since function is executed through the interactions of multiple …
Systems-level analysis of genome-wide association data
CR Farber - G3: Genes| Genomes| Genetics, 2013 - academic.oup.com
Genome-wide association studies (GWAS) have emerged as the method of choice for
identifying common variants affecting complex disease. In a GWAS, particular attention is …
identifying common variants affecting complex disease. In a GWAS, particular attention is …
Gene and pathway-based second-wave analysis of genome-wide association studies
Despite the great success of genome-wide association studies (GWAS) in identification of
the common genetic variants associated with complex diseases, the current GWAS have …
the common genetic variants associated with complex diseases, the current GWAS have …
Investigation of multi-trait associations using pathway-based analysis of GWAS summary statistics
Background Genome-wide association studies (GWAS) have been successful in identifying
disease-associated genetic variants. Recently, an increasing number of GWAS summary …
disease-associated genetic variants. Recently, an increasing number of GWAS summary …
Using genome‐wide pathway analysis to unravel the etiology of complex diseases
CC Elbers, KR van Eijk, L Franke… - … Official Publication of …, 2009 - Wiley Online Library
Several genome‐wide association studies (GWAS) have been published on various
complex diseases. Although, new loci are found to be associated with these diseases, still …
complex diseases. Although, new loci are found to be associated with these diseases, still …
Post genome-wide association analysis: dissecting computational pathway/network-based approaches
Over thousands of genetic associations to diseases have been identified by genome-wide
association studies (GWASs), which conceptually is a single-marker-based approach. There …
association studies (GWASs), which conceptually is a single-marker-based approach. There …
Identifying disease related sub-pathways for analysis of genome-wide association studies
Most methods for genome-wide association studies (GWAS) focus on discovering a single
genetic variant, but the pathogenesis of complex diseases is thought to arise from the joint …
genetic variant, but the pathogenesis of complex diseases is thought to arise from the joint …
Genome-Wide Causation Studies of Complex Diseases
Despite significant progress in dissecting the genetic architecture of complex diseases by
genome-wide association studies (GWAS), the signals identified by association analysis …
genome-wide association studies (GWAS), the signals identified by association analysis …