Chondroitin sulfate inhibits lipopolysaccharide-induced inflammation in rat astrocytes by preventing nuclear factor kappa B activation

N Cañas, R Gorina, AM Planas, J Vergés, E Montell… - Neuroscience, 2010 - Elsevier
Chondroitin sulfate (CS) is a glucosaminoglycan (GAG) currently used for the treatment of
osteoarthritis because of its antiinflammatory and antiapoptotic actions. Recent evidence …

A sulfated disaccharide derived from chondroitin sulfate proteoglycan protects against inflammation‐associated neurodegeneration

A Rolls, L Cahalon, S Bakalash, H Avidan… - The FASEB …, 2006 - Wiley Online Library
Chondroitin sulfate proteoglycan (CSPG), a matrix protein that occurs naturally in the central
nervous system (CNS), is considered to be a major inhibitor of axonal regeneration and is …

Sulfatide, a major lipid component of myelin sheath, activates inflammatory responses as an endogenous stimulator in brain-resident immune cells

SB Jeon, HJ Yoon, SH Park, IH Kim… - The Journal of …, 2008 - journals.aai.org
Sulfatide, a major lipid component of myelin sheath, participates in diverse cellular events of
the CNS, and its cellular level has recently been implicated in many inflammation …

[HTML][HTML] Antioxidant, antiinflammatory and neuroprotective actions of chondroitin sulfate and proteoglycans

J Egea, AG García, J Verges, E Montell… - Osteoarthritis and …, 2010 - Elsevier
The antiinflammatory and antiapoptotic effects of chondroitin sulfate (CS) are being used to
treat osteoarthritis. Recent evidence has revealed that those peripheral effects of CS may …

NG2, a member of chondroitin sulfate proteoglycans family mediates the inflammatory response of activated microglia

Q Gao, J Lu, Y Huo, N Baby, EA Ling, ST Dheen - Neuroscience, 2010 - Elsevier
Activation of microglial cells, the resident immune cells of the CNS causes neurotoxicity
through the release of a wide array of inflammatory mediators including proinflammatory …

Inhibitory effect of sesaminol glucosides on lipopolysaccharide-induced NF-κB activation and target gene expression in cultured rat astrocytes

SY Lee, DJ Son, YK Lee, JW Lee, HJ Lee, YW Yun… - Neuroscience …, 2006 - Elsevier
The inflammatory reaction plays an important role in the pathogenesis of the
neurodegenerative disorder including Alzheimer's disease (AD). Sesame lignan compounds …

Chondroitin sulfate reduces cell death of rat hippocampal slices subjected to oxygen and glucose deprivation by inhibiting p38, NFκB and iNOS

MD Martín-de-Saavedra, L del Barrio, N Canas… - Neurochemistry …, 2011 - Elsevier
The glycosaminoglycan chondroitin sulfate (CS) is a major constituent of the extracellular
matrix of the central nervous system where it can constitute part of the perineuronal nets …

[HTML][HTML] Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases

M Lee, EG McGeer, PL McGeer - Journal of neuroinflammation, 2016 - Springer
Background Sodium thiosulfate (STS) is an industrial chemical which has also been
approved for the treatment of certain rare medical conditions. These include cyanide …

Immunomodulatory and anti‐inflammatory effects of chondroitin sulphate

P du Souich, AG García, J Vergés… - Journal of cellular and …, 2009 - Wiley Online Library
Biochemistry of chondrotin sulphate• Mechanism of action of chondroitin sulphate‐Effect of
chondroitin sulphate on the chondrocyte‐Effect of chondroitin sulphate on the synovial …

[HTML][HTML] Inhibitor of hyaluronic acid synthesis 4-methylumbelliferone as an anti-inflammatory modulator of lps-mediated astrocyte responses

DV Chistyakov, AI Nikolskaya, SV Goriainov… - International Journal of …, 2020 - mdpi.com
Astrocytes are glial cells that play an important role in neuroinflammation. Astrocytes
respond to many pro-inflammatory stimuli, including lipopolysaccharide (LPS), an agonist of …