Discovery of prorenin/renin, or (pro) renin, receptor uncovered a novel function of (pro) renin
as receptor ligand in addition to enzyme and its precursor; the same receptor was shown to …

We present a critical review on emerging concepts on the role of (pro) renin receptor,(P) RR,
in diabetic and hypertensive nephropathy. Discovery of nonproteolytic activation of prorenin …

Prorenin and renin bind to a 350-amino acid protein called the (pro) renin receptor, which is
present on the surface and functions intracellularly. When the receptor's N terminus binds …

The (pro) renin receptor [(P) RR] specifically binds renin and prorenin and mediates their
intracellular effects. It acts as co-factor for renin and prorenin by increasing their enzymatic …

The experimental data confirmed the pivotal role of the receptor in cell surface generation of
angiotensin and suggested its potential role in tissue fibrosis via receptor activation and …

The (pro) renin receptor (PRR) binds renin and prorenin, its proenzyme inactive form.
Receptor-bound prorenin becomes enzymatically active and binding then activates the MAP …

Objectives Inhibition of (pro) renin receptor activation was demonstrated to inhibit or even
abolish the development of end-organ damage in animal models. The new renin inhibitor …

The existence of a tissue renin–angiotensin (RAS) system independent of the circulating
RAS has prompted the search for cellular binding sites for angiotensinogen and for renin in …

The discovery of a (pro) renin receptor [(P) RR] and the introduction of renin inhibitors in the
clinic have brought renin and prorenin back into the spotlight. The (P) RR binds both renin …

The discovery of a (pro) renin receptor ((P) RR) and the introduction of renin inhibitors in the
clinic has brought prorenin, the inactive proenzyme form of renin, back into the spotlight. The …