Abstract Human African trypanosomiasis (HAT), Chagas disease and leishmaniasis, which
are caused by the trypanosomatids Trypanosoma brucei, Trypanosoma cruzi and …

Taking advantage of the structural features of natural products showing anti-trypanosomatid
activity, we designed and synthesized a small library of 2-phenoxy-1, 4-naphthoquinone and …

In this study, a series of 22 pre-synthesized 7-chloro-4-amino (oxy) quinoline derivatives
was assayed in vitro as potential antichagasic agents. A primary screening against …

Over the past decades, a number of 1, 4‐naphthoquinones have been isolated from natural
resources and several of naphthoquinone derivatives with diverse structural motif have been …

Diverse polyfunctionalized tetrahydroquinolines, easily prepared using BF3. OEt2-catalyzed
three component imino Diels-Alder reaction, were tested in vitro against Trypanosoma cruzi …

A set of new aryloxy-quinones were synthesized and evaluated in vitro against the
epimastigote form of Trypanosoma cruzi and their unspecific cytotoxicity was tested on …

Quinones are attractive pharmacological scaffolds for developing new agents for the
treatment of different transmissible and non-transmissible human diseases due to their …

Target-oriented synthesis of new substituted 2-hetarylquinolines 6-19 and their in vitro
activity against endemic parasites such as Leishmania chagasi and Trypanosoma cruzi are …

The current chemotherapy for second stage human African trypanosomiasis is
unsatisfactory. A synthetic optimization study based on the lead antitrypanosomal compound …

A series of naphthoquinone derivatives has been synthesized and tested for its biological
activity against human African trypanosomiasis. The use of reverse micellar medium not only …