Background It is unclear which renal function equation, employing an isotope dilution mass
spectrometry (IDMS)-aligned creatinine assay, best predicts gentamicin clearance. Methods …

Aims We aimed to compare the performances of contemporary cystatin C (Cys)‐based GFR
equations, and the creatinine only Chronic Kidney Disease Epidemiology Collaboration …

Background Aminoglycoside clearance depends on kidney function, but the A ustralian T
herapeutic G uidelines for antibiotics (version 14, 2010) recommend initial dosing based on …

Background: The Modification of Diet in Renal Disease (MDRD) formula and a modified
version of the Cockcroft-Gault (CGm) formula adjusting for body surface area have been …

Background: Accurate estimation of kidney function is essential for safe administration of
renally cleared drugs. Current practice recommends adjusting renally eliminated drugs …

Four methods of predicting serum gentamicin concentrations (SGCs) in adult patients with
stable impaired renal function were compared. Serum samples obtained from 17 patients …

Most aminoglycoside pharmacokinetic models include an index of renal function, such as
creatinine clearance, to describe drug clearance. However, the best clinical descriptor of …

Predicted gentamicin elimination rate constants (kels) using creatinine clearance (C1cr)
estimates from seven equations were compared with kels calculated from steady‐state …

The predictability of gentamicin serum levels in patients with impaired renal function has
been a subject of controversy for several years. The reliability of prescribing aids developed …

The accuracy of predicting serum gentamicin levels based on a one-compartment open
linear pharmacokinetic model was studied. Twenty-two patients accounted for 59 serum …