[HTML][HTML] CRISPR-Cas9: a preclinical and clinical perspective for the treatment of human diseases

G Sharma, AR Sharma, M Bhattacharya, SS Lee… - Molecular Therapy, 2021 - cell.com
At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …

Mechanism and applications of CRISPR/Cas-9-mediated genome editing

M Asmamaw, B Zawdie - Biologics: targets and therapy, 2021 - Taylor & Francis
Clustered regularly interspaced short palindromic repeat (CRISPR) and their associated
protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in …

The CRISPR-Cas9 system: A new dawn in gene editing

NH Shafie, M Saleem, EJ Moses, S Razila… - Journal of Bioanalysis …, 2014 - hal.science
The CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats with CRISPR-
associated protein 9) system is a genome editing system that is easy to design, highly …

Cancer Research Using Crispr/Cas9 Gene Editing Technology

Y Li, B Zhang - Highlights in Science, Engineering and Technology, 2023 - drpress.org
Gene editing technology has completely transformed the life sciences and medical
treatment, because it makes precise and stable genetic alterations to genomic sequences …

CRISPR–Cas9 for drug discovery in oncology

SM Guichard - Annual Reports in Medicinal Chemistry, 2017 - Elsevier
Drug discovery is a complex enterprise bringing together a variety of skills and techniques.
Oncology drug discovery has taken advantage of cancer genetics to identify drug molecules …

CRISPR-Directed Gene Editing as a Method to Reduce Chemoresistance in Lung Cancer Cells

N Rivera-Torres, P Bialk, EB Kmiec - Cancer Systems and Integrative …, 2023 - Springer
We are advancing a novel strategy for the treatment of solid tumors by employing CRISPR-
directed gene editing to reduce levels of standard of care required to halt or reverse the …

[HTML][HTML] CRISPR: a journey of gene-editing based medicine

Z Golkar - Genes & Genomics, 2020 - Springer
Abstract CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) is one of the
hallmark of biological tools, contemplated as a valid and hopeful alternatives to genome …

[HTML][HTML] CRISPR/Cas9: transcending the reality of genome editing

S Chira, D Gulei, A Hajitou, AA Zimta… - … Therapy-Nucleic Acids, 2017 - cell.com
With the expansion of the microbiology field of research, a new genome editing tool arises
from the biology of bacteria that holds the promise of achieving precise modifications in the …

[HTML][HTML] CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer

M Vaghari-Tabari, P Hassanpour… - Cellular & Molecular …, 2022 - Springer
The CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and
archaea. Various studies have shown that it is possible to target a wide range of human …

Research Progress of CRISPR-Cas9 Gene Editing Technology in Cancer Therapy.

D Yidan, C Chen - Journal of Laser Biology/Acta Laser …, 2022 - search.ebscohost.com
CRISPR-Cas9, which is characterized by simplicity, effectiveness and direct targeting, can
be used to treat some incurable genetic diseases by editing DNA sequence. In recent years …