Regulation of apoptotic signaling pathways by 5α-dihydrotestosterone and 17β-estradiol in immature rat Sertoli cells

VL Simoes, MG Alves, AD Martins, TR Dias… - The Journal of steroid …, 2013 - Elsevier
Apoptosis is an important regulatory event in testicular homeostasis and optimization of
sperm production. Sertoli cells (SCs) form the blood–testis barrier creating a special …

Oestrogens as apoptosis regulators in mammalian testis: angels or devils?

S Correia, HJ Cardoso, JE Cavaco… - Expert reviews in …, 2015 - cambridge.org
In the mammalian testis, spermatogenesis is a highly coordinated process of germ cell
development, which ends with the release of 'mature'spermatozoa. The fine regulation of …

17β-Estradiol activates GPER-and ESR1-dependent pathways inducing apoptosis in GC-2 cells, a mouse spermatocyte-derived cell line

A Chimento, R Sirianni, I Casaburi, C Ruggiero… - Molecular and cellular …, 2012 - Elsevier
In mammals, spontaneous apoptosis is observed particularly in differentiating
spermatogonia and in spermatocytes. 17β-Estradiol (E2) in primary rat pachytene …

Ethanol induces mouse spermatogenic cell apoptosis in vivo through over‐expression of Fas/Fas‐L, p53, and caspase‐3 along with cytochrome c translocation and …

K Jana, N Jana, DK De, SK Guha - Molecular reproduction and …, 2010 - Wiley Online Library
Although it has been well established that spermatogenic cells undergo apoptosis when
treated with ethanol, the molecular mechanisms behind it remain to be investigated. Adult …

Deciphering the pathways of germ cell apoptosis in the testis

APS Hikim, Y Lue, M Diaz-Romero, PH Yen… - The Journal of steroid …, 2003 - Elsevier
A growing body of evidence demonstrates that germ cell death both spontaneous (during
normal spermatogenesis) and that induced by suppression of hormonal support or …

Role of 17β-estradiol and testosterone in apoptosis

A Vasconsuelo, L Pronsato, AC Ronda, R Boland… - Steroids, 2011 - Elsevier
17β-Estradiol (E2) and Testosterone (T) exert actions in most animal tissues, in addition to
the reproductive system. Thus, both sex steroid hormones affect growth and different cell …

Male germ cell apoptosis

V Pentikäinen, L Dunkel, K Erkkilä - The Developing Testis, 2003 - karger.com
This review aims at characterising the process of male germ cell death, focusing on the role
of testicular steroid hormones, the role of two important induction pathways of apoptosis, the …

17Beta-estradiol signaling and regulation of proliferation and apoptosis of rat Sertoli cells

C Royer, TFG Lucas, MFM Lazari… - Biology of …, 2012 - academic.oup.com
The aim of the present study was to investigate the intracellular signaling events
downstream of the classical estrogen receptors (ESRs) and G protein-coupled estrogen …

Apoptosis is a demanding selective tool during the development of fetal male germ cells

I Bejarano, AB Rodríguez, JA Pariente - Frontiers in cell and …, 2018 - frontiersin.org
Apoptosis is widely known to play a major role on diseases related to male infertility.
Diseases of the male genital tract as defective spermatogenesis, decreased sperm motility …

Insulin deprivation decreases caspase‐dependent apoptotic signaling in cultured rat sertoli cells

TR Dias, L Rato, AD Martins, VL Simões… - International …, 2013 - Wiley Online Library
Insulin is essential for the regulation of glucose homeostasis. Insulin dysfunction occurs in
several pathologies, such as diabetes mellitus, which is associated with fertility problems …