Elimination of germ cells via apoptosis occurs spontaneously under normal physiologic
conditions and is often heightened after chemical-induced testicular injury. Though many …

From the viewpoint of improving germ cell production and treatment of testicular cancers,
understanding the control of testicular cell death is of great relevance. One of the prominent …

Cellular apoptosis is one of the prominent processes observed in testicular development
and normal spermatogenesis. This is essential because mammalian spermatogenesis is a …

The detrimental effects of estrogen on testicular function provide a conceptual basis to
examine the speculative link between increased exposure to estrogens and spermatogenic …

Apoptosis occurs at any time in the ontogeny of the testis, especially during the first wave of
spermatogenesis. However, the exact mechanisms by which homeostasis of apoptosis and …

The involvement of apoptosis in germ cell degeneration in the adult rat testis after
gonadotrophin suppression has recently been shown in several studies, which have …

Programmed cell death is an evolutionarily conserved cell death process that plays a major
role during normal development and homeostasis. In many cases, the ordered execution of …

During early development, apoptosis plays a major role in the ontogeny of the germ line as a
means of regulating the germ cell: Sertoli cell ratio. In the adult, apoptosis fulfils another …

In utero exposure to chemicals with antiandrogen activity induces undescended testis,
hypospadias, and sub-or infertility. The hypospermatogenesis observed in the adult rat testis …

In this review, we will present an overview of estrogen actions in the testis from immature
and adult animals, with special emphasis on signaling mechanisms involved in the 17β …