The HIV-1 gp120 envelope protein has the intrinsic capacity to stimulate monokine secretion.

KA Clouse, LM Cosentino, KA Weih… - … (Baltimore, Md.: 1950 …, 1991 - journals.aai.org
Results and conclusions concerning the ability of HIV glycoprotein (gp) 120 to stimulate
monokine secretion have been equivocal, based on observations using natural gp120 …

Binding of recombinant HIV coat protein gp120 to human monocytes.

DS Finbloom, DL Hoover, MS Meltzer - Journal of immunology …, 1991 - journals.aai.org
Inasmuch as the exact level of CD4 Ag expression on macrophages is controversial and
because HIV may interact with macrophages in a manner different from that on T cells, we …

Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.

TK Hart, R Kirsh, H Ellens, RW Sweet… - Proceedings of the …, 1991 - National Acad Sciences
Human immunodeficiency virus (HIV) infects cells after binding of the viral envelope
glycoprotein gp120 to the cell surface recognition marker CD4. gp120 is noncovalently …

Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer

MR Capobianchi, H Ankel, F Ameglio… - AIDS research and …, 1992 - liebertpub.com
Cells infected with human immunodeficiency virus (HIV) induce antiviral activity in peripheral
blood mononuclear cells (PBMC) from healthy donors. This activity is neutralized by anti …

Synthetic Peptides Corresponding to Sequences in HIV Envelope gp41 and gp120 Enhance In Vitro Production of Interleukin-1 and Tumor Necrosis Factor but …

SK TYRING, R CAUDA, M TUMBARELLO… - Viral …, 1991 - liebertpub.com
Patients with human immunodeficiency virus (HIV) infections have aberrant production of a
number of lymphokines and monokines. Envelope glycoproteins are believed to be …

Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes.

P Westervelt, HE Gendelman… - Proceedings of the …, 1991 - National Acad Sciences
Profound differences exist in the replicative capacities of various human immunodeficiency
virus 1 isolates in primary human monocytes. To investigate the molecular basis for these …

Human immunodeficiency virus type 1 envelope glycoproteins gp120 and gp160 induce interleukin-6 production in CD4+ T-cell clones

N Oyaizu, N Chirmule, Y Ohnishi… - Journal of …, 1991 - Am Soc Microbiol
Polyclonal B-cell activation is a characteristic feature of AIDS and of the AIDS-related
complex. Since the immunoregulatory cytokine interleukin-6 (IL-6) plays a major role in …

The effects of human immunodeficiency virus recombinant envelope glycoprotein on immune cell functions in vitro

MR Shalaby, JF Krowka, TJ Gregory, SE Hirabayashi… - Cellular …, 1987 - Elsevier
The effect of human immunodeficiency virus (HIV) recombinant envelope glycoprotein 120
(rgp120) on the functions of peripheral blood mononuclear cells (PBMC) in vitro was …

Induction of lymphomonocyte activation by HIV-1 glycoprotein gp120. Possible role in AIDS pathogenesis.

MR Capobianchi - Journal of biological regulators and homeostatic …, 1996 - europepmc.org
Dysfunction of cytokine secretion pattern has been suggested to play a central role in the
immunopathogenesis of HIV infection. In fact a shift of T helper cell functions from a Th1-type …

95-and 25-kDa fragments of the human immunodeficiency virus envelope glycoprotein gp120 bind to the CD4 receptor.

A Nygren, T Bergman, T Matthews… - Proceedings of the …, 1988 - National Acad Sciences
125I-labeled gp120 (120-kDa envelope glycoprotein) from the BH10 isolate of human
immunodeficiency virus is cleaved to a limited extent with the glutamate-specific protease …