Neurovascular coupling in humans: physiology, methodological advances and clinical implications

AA Phillips, FHN Chan, MMZ Zheng… - Journal of Cerebral …, 2016 - journals.sagepub.com
Neurovascular coupling reflects the close temporal and regional linkage between neural
activity and cerebral blood flow. Although providing mechanistic insight, our understanding …

Neurovascular coupling: motive unknown

PJ Drew - Trends in neurosciences, 2022 - cell.com
In the brain, increases in neural activity drive changes in local blood flow via neurovascular
coupling. The common explanation for increased blood flow (known as functional …

Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease

H Girouard, C Iadecola - Journal of applied physiology, 2006 - journals.physiology.org
The brain is critically dependent on a continuous supply of blood to function. Therefore, the
cerebral vasculature is endowed with neurovascular control mechanisms that assure that …

Anesthesia and the quantitative evaluation of neurovascular coupling

K Masamoto, I Kanno - Journal of Cerebral Blood Flow & …, 2012 - journals.sagepub.com
Anesthesia has broad actions that include changing neuronal excitability, vascular reactivity,
and other baseline physiologies and eventually modifies the neurovascular coupling …

The neurovascular unit in brain function and disease

C Lecrux, E Hamel - Acta physiologica, 2011 - Wiley Online Library
Neurovascular coupling, or functional hyperaemia, refers to complex mechanisms of
communication between neurons, astrocytes and cerebral vessels which form the …

[HTML][HTML] Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal

YR Gao, Y Ma, Q Zhang, AT Winder, Z Liang, L Antinori… - Neuroimage, 2017 - Elsevier
Functional magnetic resonance imaging (fMRI) has allowed the noninvasive study of task-
based and resting-state brain dynamics in humans by inferring neural activity from blood …

Investigating human neurovascular coupling using functional neuroimaging: a critical review of dynamic models

C Huneau, H Benali, H Chabriat - Frontiers in neuroscience, 2015 - frontiersin.org
The mechanisms that link a transient neural activity to the corresponding increase of
cerebral blood flow (CBF) are termed neurovascular coupling (NVC). They are possibly …

The effect of different anesthetics on neurovascular coupling

MA Franceschini, H Radhakrishnan, K Thakur, W Wu… - Neuroimage, 2010 - Elsevier
To date, the majority of neurovascular coupling studies focused on the thalamic afferents'
activity in layer IV and the corresponding large spiking activity as responsible for functional …

The oxygen paradox of neurovascular coupling

C Leithner, G Royl - Journal of Cerebral Blood Flow & …, 2014 - journals.sagepub.com
The coupling of cerebral blood flow (CBF) to neuronal activity is well preserved during
evolution. Upon changes in the neuronal activity, an incompletely understood coupling …

[HTML][HTML] What is the key mediator of the neurovascular coupling response?

PS Hosford, AV Gourine - Neuroscience & Biobehavioral Reviews, 2019 - Elsevier
The mechanisms of neurovascular coupling contribute to ensuring brain energy supply is
sufficient to meet demand. Despite significant research interest, the mechanisms underlying …