[HTML][HTML] BRAF mutations in anaplastic thyroid carcinoma: implications for tumor origin, diagnosis and treatment
S Begum, E Rosenbaum, R Henrique, Y Cohen… - Modern …, 2004 - nature.com
Anaplastic thyroid carcinoma is a highly aggressive neoplasm. Affected patients typically
present with advanced disease where there is little hope for cure using conventional …
present with advanced disease where there is little hope for cure using conventional …
Oncogenic activation of MAP kinase by BRAF pseudogene in thyroid tumors
M Zou, EY Baitei, AS Alzahrani, F Al-Mohanna… - Neoplasia, 2009 - Elsevier
Activating BRAF mutations have been reported in 40% of papillary thyroid carcinomas
(PTCs). The involvement of BRAF pseudogene in thyroid tumorigenesis has not previously …
(PTCs). The involvement of BRAF pseudogene in thyroid tumorigenesis has not previously …
Clinical impact of the detection of BRAF mutations in thyroid pathology: potential usefulness as diagnostic, prognostic and theragnostic applications
S Lassalle, V Hofman, M Ilie, C Butori… - Current medicinal …, 2010 - ingentaconnect.com
A BRAF somatic mutation at residue 600 of the BRAF protein (BRAFV600E) is highly
prevalent in papillary thyroid carcinomas (PTC). This mutation occurs in approximately …
prevalent in papillary thyroid carcinomas (PTC). This mutation occurs in approximately …
Correlation between BRAF mutation and the clinicopathological parameters in papillary thyroid carcinoma with particular reference to follicular variant
RA Smith, A Salajegheh, S Weinstein, M Nassiri… - Human pathology, 2011 - Elsevier
Mutation of the BRAF gene is common in thyroid cancer. Follicular variant of papillary thyroid
carcinoma is a variant of papillary thyroid carcinoma that has created continuous diagnostic …
carcinoma is a variant of papillary thyroid carcinoma that has created continuous diagnostic …
BRAFV600E mutation in Turkish patients with papillary thyroid cancer: strong correlation with indicators of tumor aggressiveness
N Kurtulmus, M Duren, U Ince, M Cengiz Yakicier… - Endocrine, 2012 - Springer
Papillary thyroid cancer (PTC) constitutes more than 90% of the thyroid cancers. MAP
kinase/ERK pathway plays an important role in the development of several cancers. BRAF …
kinase/ERK pathway plays an important role in the development of several cancers. BRAF …
BRAFV599E Mutation Is the Leading Genetic Event in Adult Sporadic Papillary Thyroid Carcinomas
E Puxeddu, S Moretti, R Elisei, C Romei… - The Journal of …, 2004 - academic.oup.com
Activating mutations of BRAF have been identified in a variety of human cancers, most
notably melanomas and papillary thyroid carcinomas (PTCs). The aim of the present study …
notably melanomas and papillary thyroid carcinomas (PTCs). The aim of the present study …
BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Poorly Differentiated Carcinomas Arising from Papillary Carcinomas
MN Nikiforova, ET Kimura, M Gandhi… - The Journal of …, 2003 - academic.oup.com
Activating point mutations of the BRAF gene have been recently reported in papillary thyroid
carcinomas. In this study, we analyzed 320 thyroid tumors and six anaplastic carcinoma cell …
carcinomas. In this study, we analyzed 320 thyroid tumors and six anaplastic carcinoma cell …
Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA)
MR Sapio, D Posca, G Troncone… - European Journal of …, 2006 - academic.oup.com
Objective The somatic point mutation in the BRAF gene, which results in a valine-to-
glutamate substitution at residue 600 (BRAFV600E), is an ideal hallmark of papillary thyroid …
glutamate substitution at residue 600 (BRAFV600E), is an ideal hallmark of papillary thyroid …
Clinicopathological relevance of BRAF mutations in human cancer
S Pakneshan, A Salajegheh, RA Smith… - Pathology-Journal of …, 2013 - journals.lww.com
BRAF represents one of the most frequently mutated protein kinase genes in human
tumours. The mutation is commonly tested in pathology practice. BRAF mutation is seen in …
tumours. The mutation is commonly tested in pathology practice. BRAF mutation is seen in …
Immunohistochemical Detection of Mutated BRAF V600E Supports the Clonal Origin of BRAF-Induced Thyroid Cancers Along the Spectrum of Disease Progression
RA Ghossein, N Katabi, JA Fagin - The Journal of Clinical …, 2013 - academic.oup.com
Background: The mutated BRAF V600E protein has been specifically detected in papillary
thyroid carcinomas (PTCs) using immunohistochemical (IHC) analysis. The clonal origin of …
thyroid carcinomas (PTCs) using immunohistochemical (IHC) analysis. The clonal origin of …