Sex and estrogen influence drug abuse

ME Carroll, WJ Lynch, ME Roth, AD Morgan… - Trends in …, 2004 - cell.com
Evidence is accumulating that the etiology, epidemiology, consequences and mechanisms
that underlie drug abuse are different in males and females. In this review, we present …

Gender effects on drug use, abuse, and dependence: a special analysis of results from the National Survey on Drug Use and Health

JH Cotto, E Davis, GJ Dowling, JC Elcano, AB Staton… - Gender medicine, 2010 - Elsevier
Background: Gender is increasingly being studied for risk and protective factors underlying
substance abuse and addiction. Objective: The aim of this study was to assess gender …

Gender differences in prevalence of substance use disorders among individuals with lifetime exposure to substances: results from a large representative sample

S Lev‐Ran, Y Le Strat, S Imtiaz… - The American journal …, 2013 - Wiley Online Library
Background and Objectives Research regarding substance use and substance use
disorders (SUDs) shows significant gender differences in prevalence of substance use and …

Sex-gender differences in drug abuse: a shift in the burden of proof?

CL Wetherington - Experimental and clinical psychopharmacology, 2007 - psycnet.apa.org
In the early years of NIDA-supported drug abuse research, much of the research on women
was treatment related and conducted out of concern for their pregnancy status. Since then …

Females are more vulnerable to drug abuse than males: evidence from preclinical studies and the role of ovarian hormones

JJ Anker, ME Carroll - Biological basis of sex differences in …, 2011 - Springer
Human and animal research indicates the presence of sex differences in drug abuse. These
data suggest that females, compared to males, are more vulnerable to key phases of the …

Drug treatment: explaining the gender paradox

R Florentine, MD Anglin, V Gil-Rivas… - Substance Use & …, 1997 - Taylor & Francis
There is something of a gender paradox in drug user treatment. Research consistently
indicates that women possess “risk factors” associated with drug use relapse, yet women are …

Estradiol as a mechanism for sex differences in the development of an addicted phenotype following extended access cocaine self-administration

CP Ramôa, SE Doyle, DW Naim… - …, 2013 - nature.com
Women progress more rapidly after initial cocaine use to addiction as compared with men.
Similarly, female rats appear to require less cocaine exposure before developing an …

Ovarian hormones and propensity to drug relapse: a review

A Hudson, JA Stamp - Neuroscience & Biobehavioral Reviews, 2011 - Elsevier
Sex differences have been reported in various phases of substance abuse, including
relapse. In general, women show greater propensity to drug relapse than men, owing …

Gender differences in clinical outcomes for cocaine dependence: randomized clinical trials of behavioral therapy and disulfiram

EE DeVito, TA Babuscio, C Nich, SA Ball… - Drug and Alcohol …, 2014 - Elsevier
Background Despite extensive research on gender differences in addiction, there are
relatively few published reports comparing treatment outcomes for women versus men …

Gender issues in the treatment of abusers of alcohol, nicotine, and other drugs

A Toneatto, LC Sobell, MB Sobell - Journal of Substance Abuse, 1992 - Elsevier
This review considers gender issues in the recent literature for alcohol, nicotine, and other
psychoactive drug abuse and for each of the three drug types reports:(1) the ratio of men to …