The involvement of transient receptor vanilloid type-1 (TRPV1) channels in pain modulation
by the brain remains understudied. The rostroventromedial medulla (RVM) plays a key role …

Transient receptor potential vanilloid type 1 (TRPV1) receptor is a ligand-gated non-
selective cation channel activated by heat (> 43° C), low pH and endogenous lipid …

Diabetic neuropathic pain (DNP) is one of the most common clinical manifestations of
diabetes mellitus (DM), which is characterized by prominent mechanical allodynia (DMA) …

Diabetic mechanical allodynia (DMA) is a common manifestation in patients with diabetes
mellitus, and currently, no effective treatment is available. Transient receptor potential …

Diabetic neuropathy has a profound impact in the quality of life of patients who frequently
complain of pain. The mechanisms underlying diabetic neuropathic pain (DNP) are no …

Painful diabetic neuropathy is a disease of the peripheral sensory neuron with impaired
opioid responsiveness. Since μ-opioid receptor (MOR) activation can inhibit the transient …

Abstract The Transient Receptor Potential Vanilloid 1 (TRPV1) non-selective cation channel
predominantly expressed in primary sensory neurons of the dorsal root and trigeminal …

Transient receptor potential vanilloid type 1 (TRPV1) receptor is a non selective ligand-
gated cation channel activated by capsaicin, heat, protons and endogenous lipids termed …

Transient receptor potential vanilloid type 1 (TRPV1), a ligand-gated cation channel, is a
polymodal nocitransducer widely expressed within pain transmitting/modulating areas of the …

Pharmacological therapies in type 1 diabetes for efficient control of glycemia and changes in
pain alterations due to diabetic neuropathy are a continuous challenge. Transient receptor …