Although iron is essential in maintaining the function of the central nervous system, it is a
potent source of reactive oxygen species. Excessive iron accumulation occurs in many …

Iron is both essential for maintaining a spectrum of metabolic processes in the central
nervous system and elsewhere, and potent source of reactive oxygen species. Redox …

Many lines of evidence indicate that oxidative stress is one of the earliest events in the
genesis of Alzheimer's disease (AD). Iron is a transition metal capable of generating …

Many evidences indicate that oxidative stress plays a significant role in a variety of human
disease states, including neurodegenerative diseases. Iron is an essential metal for almost …

It is now established that oxidative stress is one of the earliest, if not the earliest, change that
occurs in the pathogenesis of Alzheimer's disease (AD). Consistent with this, mild cognitive …

Iron overload is a hallmark of many neurodegenerative processes such as Alzheimer's,
Parkinson's, and Huntington's diseases. Unbound iron accumulated as a consequence of …

The present article reviews the roles and interactions of iron and neuroinflammation in
Alzheimer's disease. It highlights the importance of neuroinflammatory changes in the glial …

Iron (Fe) is an essential element for many metabolic processes, serving as a cofactor for
heme and nonheme proteins. Cellular iron deficiency arrests cell growth and leads to cell …

Iron plays a role for the biogenesis of two important redox‐reactive prosthetic groups of
enzymes, iron sulphur clusters (ISC) and heme. A part of these biosynthetic pathways takes …

Reactive oxygen species (ROS) play a key role in the neurodegeneration processes.
Increased oxidative stress damages lipids, proteins, and nucleic acids in brain tissue, and it …