Significance: The endoplasmic reticulum (ER) is a specialized organelle for the folding and
trafficking of proteins, which is highly sensitive to changes in intracellular homeostasis and …

The endoplasmic reticulum (ER) is a well-orchestrated protein-folding machine composed of
protein chaperones, proteins that catalyze protein folding, and sensors that detect the …

Cellular mechanisms governing redox homeostasis likely involve their integration with other
stresses. Endoplasmic reticulum (ER) stress triggers complex adaptive or proapoptotic …

The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main
functions include protein synthesis, proper protein folding, protein modification, and the …

The endoplasmic reticulum (ER) is the principal cellular organelle in which correct folding
and maturation of transmembrane, secretory, and ER-resident proteins occur. Research …

Unfolded proteins and other conditions affecting endoplasmic reticulum (ER) homeostasis
cause ER stress. The cell reacts to ER stress by activation of the unfolded protein response …

Endoplasmic reticulum (ER) is a dynamic organelle orchestrating the folding and post-
translational maturation of almost all membrane proteins and most secreted proteins. These …

A variety of debilitating diseases including diabetes, Alzheimer's, Huntington's, Parkinson's,
and prion-based diseases are linked to stress within the endoplasmic reticulum (ER). Using …

Oxidative stress is caused by an imbalance in cellular redox state due to the accumulation of
reactive oxygen species (ROS). While homeostatic levels of ROS are important for cell …

The endoplasmic reticulum (ER) is a critical organelle for normal cell function and
homeostasis. Disturbance in the protein folding process in the ER, termed ER stress, leads …