Neurons in the lateral amygdala (LA) receive glutamatergic sensory input from the auditory
thalamus and auditory cortex, and these inputs can be modulated by serotonin (5-HT). In the …

Current evidence suggests that anxiety has a neurobiologic basis. It is thought to be caused
by dysfunction of one or more neurotransmitters and their receptors. Most data, which are …

Although serotonergic neural systems have been implicated in the control of anxiety for a
number of years, evidence in favour of this role is controversial. The present experiments …

Although clinical observations suggest that humans with amygdala damage have abnormal
fear reactions and a reduced experience of fear [1–3], these impressions have not been …

Rationale Contextual fear conditioning can produce both changes in hippocampal synaptic
efficacy and potentiation of subsequent fear learning. Objectives In this study, we tested …

Fear of anxiety symptoms (anxiety sensitivity) has been implicated in the etiology and
maintenance of panic disorder, and has been shown to improve with cognitive-behavioral …

Conditioned fear plays a key role in anxiety disorders as well as depression and other
neuropsychiatric conditions. Understanding how neuromodulators drive the associated …

BACKGROUND: Like fear conditioning, the acquisition phase of extinction involves new
learning that is mediated by the amygdala. During extinction training, the conditioned …

Atypical antipsychotic drugs (atypical APDs), such as clozapine, ORG5222, and olanzapine,
have been suggested to possess anxiolytic activity in the conflict test and elevated plus …

Serotonin (5-HT) plays a key role in the neural circuitry mediating unconditioned and
conditioned fear responses related to panic and generalized anxiety disorders. The …