Vertebrates possess lineage-specific characteristics. These include paired anterior sense
organs and a robust, modular head skeleton built of cellular cartilage and bone. All of these …

The neural crest is a vertebrate-specific embryonic stem cell population that gives rise to a
vast array of cell types throughout the animal body plan. These cells are first born at the …

The neural crest is regionalized along the anteroposterior axis, as demonstrated by
foundational lineage-tracing experiments that showed the restricted developmental potential …

From the initial discovery of the neural crest over 150 years ago to the seminal studies of Le
Douarin and colleagues in the latter part of the twentieth century, understanding of the …

In their seminal 1983 paper, Gans and Northcutt proposed that evolution of the vertebrate
'new head'was made possible by the advent of the neural crest and cranial placodes. The …

As vertebrates evolved from protochordates, they shifted to a more predatory lifestyle, and
radiated and adapted to most niches of the planet. This process was largely facilitated by the …

Urochordates (ascidians) have recently supplanted cephalochordates (amphioxus) as the
extant sister taxon of vertebrates. Given that urochordates possess migratory cells that have …

The neural crest is a multipotent and migratory cell type that forms transiently in the
developing vertebrate embryo. These cells emerge from the central nervous system, migrate …

The neural crest is a fascinating embryonic population unique to vertebrates that is endowed
with remarkable differentiation capacity. Thought to originate from ectodermal tissue, neural …

The neural crest is an embryonic cell type that is unique to vertebrates and forms numerous,
diverse derivatives. For example, these cells give rise to critical components of the …