Mitochondria are key organelles involved in energy production, functioning as the metabolic
hubs of cells. Recent findings emphasize the emerging role of the mitochondrion as a key …

Mitochondria, the dynamic organelles and power house of eukaryotic cells function as
metabolic hubs of cells undergoing continuous cycles of fusion and fission. Recent findings …

Highlights•Mitochondrial fission/fusion and mitophagy regulators modulate RLR
responses.•NLRP3 activation is dependent on mitochondrial localization and mROS.•Cyclic …

Mitochondria are versatile organelles and essential components of numerous biological
processes such as energy metabolism, signal transduction, and cell fate determination. In …

Canonical functions of mitochondria include the regulation of cellular survival, orchestration
of anabolic and metabolic pathways, as well as reactive oxygen species (ROS) signaling …

The nod‐like receptor protein 3 (NLRP3) inflammasome drives inflammation in response to
mitochondrial dysfunction. As metabolic powerhouses with prokaryotic ancestry …

NLRP3 inflammasome‐dependent inflammatory responses are triggered by a variety of
signals of host danger, including infection, tissue damage and metabolic dysregulation. How …

A growing literature indicates that mitochondria are key participants in innate immune
pathways, functioning as both signaling platforms and contributing to effector responses. In …

Mitochondria are cellular organelles essential for multiple biological processes, including
energy production, metabolites biosynthesis, cell death, and immunological responses …

The innate immune system has a key role in the mammalian immune response. Recent
research has demonstrated that mitochondria participate in a broad range of innate immune …