Variation in an animal's behavioral state is linked to fluctuations in brain activity and
cognitive ability. In the neocortex, state-dependent circuit dynamics may reflect …

Experimental work across species has demonstrated that spontaneously generated
behaviors are robustly coupled to variations in neural activity within the cerebral cortex …

Fluctuations in brain and behavioral state are supported by broadly projecting
neuromodulatory systems. In this study, we use mesoscale two-photon calcium imaging to …

ACh is a signaling molecule in the mammalian CNS, with well-documented influence over
cognition and behavior. However, the nature of cholinergic signaling in the brain remains …

Cognition arises from the dynamic flow of neural activity through the brain. To capture these
dynamics, we used mesoscale calcium imaging to record neural activity across the dorsal …

Cholinergic modulation of cortex powerfully influences information processing and brain
states, causing robust desynchronization of local field potentials and strong decorrelation of …

Complex cognitive processes require neuronal activity to be coordinated across multiple
scales, ranging from local microcircuits to cortex-wide networks. However, multiscale cortical …

Acetylcholine (ACh) signaling shapes neuronal circuit development and underlies specific
aspects of cognitive functions and behaviors, including attention, learning, memory and …

Cholinergic neurotransmission throughout the neocortex and hippocampus regulates
arousal, learning, and attention. However, owing to the poorly characterized timing and …

Acetylcholine is the primary neuromodulator involved in cortical arousal in mammals.
Cholinergic modulation is involved in conscious awareness, memory formation and attention …