Results of experimental and genetic studies have highlighted the role of the IL-23/IL-17 axis
in the pathogenesis of inflammatory bowel disease (IBD). IL-23–driven inflammation has …

Abstract Polymorphisms of interleukin (IL)-23R and signaling components are associated
with several autoimmune diseases, including inflammatory bowel diseases (IBD). Similar to …

The etiology of inflammatory bowel disease is unknown but available evidence suggests
that a deregulated immune response towards the commensal bacterial flora is responsible …

Although very high levels of interleukin (IL)-1β are present in the intestines of patients
suffering from inflammatory bowel diseases (IBD), little is known about the contribution of IL …

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal
tract involving aberrant activation of innate and adaptive immune responses. We have used …

IL-23 regulation is a central event in the pathogenesis of the inflammatory bowel diseases.
We demonstrate that IFN-γ has anti-inflammatory properties in the initiation phase of IL-23 …

This study analyzed IL-23p19 expression in inflamed mucosa of IBD and the role in the
induction of IEL and NK cell activation as well as Th17 cell differentiation. Expression of IL …

Mice deficient in the IL-10 pathway are the most widely used models of intestinal
immunopathology. IL-17A is strongly implicated in gut disease in mice and humans, but …

Abstract Interleukin (IL)-17C is a novel member of the IL-17 cytokine family. Its function in
human inflammatory bowel disease (IBD) remains elusive as its role in colonic inflammation …

Interleukin (IL)-22–producing group 3 innate lymphoid cells (ILC3) promote mucosal healing
and maintain barrier integrity, but how microbial signals are integrated to regulate mucosal …