The dominant assumption central to most treatments for sickle cell anemia has been that
replacement of sickle hemoglobin (HbS) by fetal hemoglobin (HbF) would have major …

Sickle cell anaemia is associated with a mutant haemoglobin, HbS, which forms polymers in
the red blood cells of patients. The primary role of the HbS polymerization for the …

Sickle hemoglobin (HbS) is a point mutation of the two β subunits in normal Hb (HbA) that
leads to nucleated polymerization and accompanying pathology. We measured the rates of …

The polymerization of sickle hemoglobin involves the assembly of 14 stranded fibers, which
are found in dense multibranched arrays (Briehl, 1995; White & Heagan, 1970) called …

Sickle cell anemia is a debilitating genetic disease that affects hundreds of thousands of
babies born each year worldwide. Its primary pathogenic event is the polymerization of a …

A double nucleation mechanism for the polymerization of sickle hemoglobin is described.
The mechanism accounts for all of the major kinetic observations: the appearance of a …

The homogeneous nucleation rate for sickle hemoglobin polymerization has been
measured for concentrations from 3.9 to 4.9 mM and temperatures from 13 degrees C to 35 …

Polymerization of sickle cell hemoglobin (HbS) in deoxy state is one of the basic events in
the pathophysiology of sickle cell anemia. For insight into the polymerization process, we …

This chapter reviews current understanding of the molecular and cellular basis of the
pathophysiology of sickle‐cell anemia, with emphasis on the biophysics of the intracellular …

Using a combination of laser photolysis and temperature-jump techniques, the kinetics of
hemoglobin S polymerization have been studied over a wide range of delay times (10− 3 to …