A cluster of amino acid residues located in the AB-GH region of the α-chain are shown in
intra-double strand axial interactions of the hemoglobin S (HbS) polymer. However, αLeu …

We have measured homogeneous and heterogeneous nucleation rates of sickle
hemoglobin (HbS) in the presence of a strongly binding deletion mutant of the cytoplasmic …

Sickle cell disease, a common single gene disorder, has a complex pathophysiology that at
its root is initiated by the polymerization of deoxy sickle hemoglobin. Sickle vasoocclusion …

Natural observations can often provide important clues for how therapies can be developed
to ameliorate disease. Disorders of β-hemoglobin, including sickle cell disease and β …

Reversing the developmental switch from fetal hemoglobin (HbF, α2γ2) to adult hemoglobin
(HbA, α2β2) is an important therapeutic approach in sickle cell disease (SCD) and β …

The melting of sickle cell hemoglobin (HbS) polymers was induced by rapid dilution using a
stopped-flow apparatus. The kinetics of polymer melting were monitored using light …

Sickle cell disease (SCD) is caused by a variant hemoglobin molecule that polymerizes
inside red blood cells (RBCs) in reduced oxygen tension. Treatment development has been …

Fetal hemoglobin (HbF) usually consists of 4 to 10% of total hemoglobin in adults of African
descent with sickle cell anemia. Rarely, their HbF levels reach more than 30%. High HbF …

We report the results of thermodynamic and kinetic studies on the gelation of mixtures of
sickle cell (S) deoxyhemoglobin with normal human adult (A) and fetal (F) …