Animal models and human studies have been useful in dissecting the molecular
mechanisms of renal disease and finding new disease targets; however, translation of these …

Advancing beyond the genome, the field of proteomics now demonstrates great promise for
providing improved means for early disease diagnostics, patient stratification, monitoring …

Nephrotic syndrome is not a single disease; rather, it is a term for numerous diseases and
pathological types. Renal biopsy is of use in determining the diagnosis and prognosis, and …

One of the major challenges modern nephrology should face is the identification of
biomarkers that are associated with histopathological patterns or defined pathogenic …

The analysis of protein biomarkers in urine is expected to lead to advances in a variety of
clinical settings. Several characteristics of urine including a low-protein matrix, ease of …

Abstract The Human Kidney and Urine Proteome Project (HKUPP) was initiated to promote
proteomics research in the nephrology field, to better understand kidney functions as well as …

The increase in progressive kidney disease, resulting in a constantly rising prevalence of
endstage renal disease (ESRD), urgently warrants the development of more effective …

PURPOSE: Proteomics is a rapidly growing new discipline that has the potential to increase
and improve the understanding of protein function and interaction in the context of systems …

Sparked by the article from Lescuyer and colleagues in a recent issue, we aim here to
further encourage interest in and discussion of clinically relevant biomarker research. We …

The aim of this manuscript is to initiate a constructive discussion about the definition of
clinical proteomics, study requirements, pitfalls and (potential) use. Furthermore, we hope to …