Urinary proteomics and molecular determinants of chronic kidney disease: possible link to proteases

S Filip, C Pontillo, J Peter Schanstra… - Expert review of …, 2014 - Taylor & Francis
Chronic kidney disease (CKD) is the gradual decrease in renal function. Currently available
biomarkers are effective only in detecting late stage CKD. Biomarkers of early stage CKD …

Proteomics and autoimmune kidney disease

BH Rovin, JB Klein - Clinical immunology, 2015 - Elsevier
Proteomics has long been considered an ideal platform, and urine an ideal source for
biomarker discovery in human autoimmune kidney diseases. A number of studies have …

Proteomic technologies for the identification of disease biomarkers in serum: advances and challenges ahead

S Ray, PJ Reddy, R Jain, K Gollapalli, A Moiyadi… - …, 2011 - Wiley Online Library
Serum is an ideal biological sample that contains an archive of information due to the
presence of a variety of proteins released by diseased tissue, and serum proteomics has …

Expanding the proteome two‐dimensional gel electrophoresis reference map of human renal cortex by peptide mass fingerprinting

F Magni, C Sarto, C Valsecchi, S Casellato… - …, 2005 - Wiley Online Library
Proteomics methodologies hold great promise in basic renal research and clinical
nephrology. The classical approach for proteomic analysis couples two‐dimensional gel …

Proteomic strategies for biomarker identification: progress and challenges.

ET Fung, GL Wright Jr, EA Dalmasso - Current opinion in molecular …, 2000 - europepmc.org
The simplest definition of a biomarker is a molecule that indicates an alteration in physiology
from normal. A more practical definition of a biomarker would require clinical utility of this …

[HTML][HTML] Proteomics and disease revisited: the challenge of providing proteomic tools into clinical practice

TE Fehniger, G Marko-Varga - Journal of Proteome Research, 2010 - ACS Publications
Low-density lipoprotein. Alanine transaminase. Troponin I. Alpha-1-antitrypsin. Clinicians
throughout the world rely on standardized laboratory reference values of proteins to …

Proteogenomics: key driver for clinical discovery and personalized medicine

R Barbieri, V Guryev, CA Brandsma, F Suits, R Bischoff… - Proteogenomics, 2016 - Springer
Proteogenomics is a multi-omics research field that has the aim to efficiently integrate
genomics, transcriptomics and proteomics. With this approach it is possible to identify new …

Urine proteomics in clinical applications: technologies, principal considerations and clinical implementation.

A Albalat, H Mischak, W Mullen - Prilozi, 2011 - europepmc.org
The technology platforms for proteome analysis have advanced considerably over the last
few years. Due to these improvements the number of studies on the analysis of the …

Clinical proteomics: Closing the gap from discovery to implementation

M Frantzi, A Latosinska, G Kontostathi, H Mischak - Proteomics, 2018 - Wiley Online Library
Clinical proteomics, the application of proteome analysis to serve a clinical purpose,
represents a major field in the area of proteome research. Over 1000 manuscripts on this …

Challenges of genomics and proteomics in nephrology

S Stojnev, M Pejcic, Z Dolicanin, LJ Velickovic… - Renal failure, 2009 - Taylor & Francis
An increasing number of patients suffering from renal diseases and limitations in standard
diagnostic and therapeutic approaches has created an intense interest in applying …