[HTML][HTML] Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence via the interferon protein IFITM3
M Borghesan, J Fafián-Labora, O Eleftheriadou… - Cell Reports, 2019 - cell.com
Senescence is a cellular phenotype present in health and disease, characterized by a stable
cell-cycle arrest and an inflammatory response called senescence-associated secretory …
cell-cycle arrest and an inflammatory response called senescence-associated secretory …
[HTML][HTML] Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype
L Terlecki-Zaniewicz, I Lämmermann, J Latreille… - Aging (Albany …, 2018 - ncbi.nlm.nih.gov
Loss of functionality during aging of cells and organisms is caused and accompanied by
altered cell-to-cell communication and signalling. One factor thereby is the chronic …
altered cell-to-cell communication and signalling. One factor thereby is the chronic …
[HTML][HTML] Extracellular vesicles as new players in cellular senescence
L Urbanelli, S Buratta, K Sagini, B Tancini… - International Journal of …, 2016 - mdpi.com
Cell senescence is associated with the secretion of many factors, the so-called “senescence-
associated secretory phenotype”, which may alter tissue microenvironment, stimulating the …
associated secretory phenotype”, which may alter tissue microenvironment, stimulating the …
Uncoupling the senescence-associated secretory phenotype from cell cycle exit via interleukin-1 inactivation unveils its protumorigenic role
L Lau, A Porciuncula, A Yu, Y Iwakura… - Molecular and cellular …, 2019 - Am Soc Microbiol
Cellular senescence has emerged as a potent tumor suppressor mechanism in numerous
human neoplasias. Senescent cells secrete a distinct set of factors, collectively termed the …
human neoplasias. Senescent cells secrete a distinct set of factors, collectively termed the …
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells
implement a complex pro-inflammatory response termed the senescence-associated …
implement a complex pro-inflammatory response termed the senescence-associated …
[HTML][HTML] Exploring the communication of the SASP: dynamic, interactive, and adaptive effects on the microenvironment
J Giroud, I Bouriez, H Paulus, A Pourtier… - International Journal of …, 2023 - mdpi.com
Cellular senescence is a complex cell state that can occur during physiological ageing or
after exposure to stress signals, regardless of age. It is a dynamic process that continuously …
after exposure to stress signals, regardless of age. It is a dynamic process that continuously …
[HTML][HTML] Extracellular vesicles and aging
PD Robbins - Stem cell investigation, 2017 - ncbi.nlm.nih.gov
Aging and the chronic diseases associated with aging place a tremendous burden on our
healthcare system. As our world population ages dramatically over the next decades, this …
healthcare system. As our world population ages dramatically over the next decades, this …
[HTML][HTML] Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells
V Severino, N Alessio, A Farina, A Sandomenico… - Cell death & …, 2013 - nature.com
Cellular senescence is the permanent arrest of cell cycle, physiologically related to aging
and aging-associated diseases. Senescence is also recognized as a mechanism for limiting …
and aging-associated diseases. Senescence is also recognized as a mechanism for limiting …
Roles and mechanisms of cellular senescence in regulation of tissue homeostasis
N Ohtani, E Hara - Cancer science, 2013 - Wiley Online Library
Cellular senescence is the state of irreversible cell cycle arrest that can be induced by a
variety of potentially oncogenic stimuli and has therefore long been considered to suppress …
variety of potentially oncogenic stimuli and has therefore long been considered to suppress …
[HTML][HTML] The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype
R Wallis, H Mizen, CL Bishop - Mechanisms of ageing and development, 2020 - Elsevier
Senescence is a state of proliferative arrest which has been described as a protective
mechanism against the malignant transformation of cells. However, senescent cells have …
mechanism against the malignant transformation of cells. However, senescent cells have …