Calorie restriction (CR) extends lifespan from yeast to mammals. SIRT6 is a member of the
sirtuin family of NAD+-dependent histone deacetylases, which is responsible for mediating …

Members of the sirtuin (SIRT) family of NAD-dependent deacetylases promote longevity in
multiple organisms. Deficiency of mammalian SIRT6 leads to shortened life span and an …

Aims Alzheimer's disease (AD) is the most prevalent age-related disease and the most
common cause of dementia in the elderly. Its hallmark neuropathological features are the …

Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …

Aging is a biological phenomenon in which the structure and function of organisms declining
with the increasing of age. It has become a major risk factor of human diseases, including …

Ageing is the most significant risk factor for a range of prevalent diseases, including cancer,
cardiovascular disease, and diabetes. Accordingly, interventions are needed for delaying or …

The extension in human lifespan in the last century results in a significant increase in
incidence of age related diseases. It is therefore crucial to identify key factors that control …

Mammalian sirtuins, Sirt1–Sirt7, are recently discovered regulatory proteins, which play
decisive roles in cellular metabolism, stress resistance, and proliferation. Sirtuins are …

Ageing and obesity have common hallmarks: altered glucose and lipid metabolism, chronic
inflammation and oxidative stress are some examples. The downstream effects of SIRT1 …

Silent information regulator 2 (Sir2/Sirt1), a member of the sirtuin family of class III histone
deacetylases, has been implicated extensively in lifespan extension and is a prominent drug …