Aims/hypothesis The aims of this study were to determine the role of lipolysis in
hypoglycaemia and define the underlying intracellular mechanisms. Methods Nine healthy …

OBJECTIVE Changes in glucose metabolism occurring during counterregulation are, in part,
mediated by increased plasma free fatty acids (FFAs), as a result of hypoglycemia-activated …

Aims/hypothesis Impaired regulation of lipolysis and accumulation of lipid intermediates may
contribute to obesity-related insulin resistance and type 2 diabetes mellitus. We investigated …

Aims/hypothesis Lack of insulin and infection/inflammation are the two most common causes
of diabetic ketoacidosis (DKA). We used insulin withdrawal followed by insulin …

Context: Endocrine defensive mechanisms provide for energy supply during hypoglycemia.
Intramyocellular lipids (IMCL) were recently shown to contribute to energy supply during …

Obesity-induced insulin resistance is a major risk factor for the development of type 2
diabetes. Basal fat cell lipolysis (ie, fat cell triacylglycerol breakdown into fatty acids and …

Suppression of lipolysis by acipimox is known to improve insulin-stimulated glucose
disposal, and this is an important phenomenon. The mechanism has been assumed to be …

To determine whether insulin regulation of lipolysis is abnormal in subjects with poorly
controlled insulin-dependent diabetes mellitus (IDDM), free-fatty acid flux ([1-14C] palmitate) …

Adipose Tissue Lipolysis Revisited (Again!): Lactate Involvement in Insulin Antilipolytic Action
Page 1 Cell Metabolism Previews Adipose Tissue Lipolysis Revisited (Again!): Lactate …

The present study was designed to examine the effect of pulsatile versus continuous insulin
delivery on glucose and lipid metabolism in insulin-resistant subjects. Six obese women …