Suppression of systemic, intramuscular, and subcutaneous adipose tissue lipolysis by insulin in humans

M Stumvoll, S Jacob, HG Wahl, B Hauer… - The Journal of …, 2000 - academic.oup.com
In addition to sc and visceral fat deposits, muscle has been shown to contain relevant
amounts of lipids whose breakdown is subject to hormonal regulation. The aim of the …

Effects of hypertriglyceridemia with or without NEFA elevation on β-cell function and insulin clearance and sensitivity

D Tricò, E Rebelos, B Astiarraga, S Baldi… - The Journal of …, 2024 - academic.oup.com
Context Hypertriglyceridemia is a risk factor for developing type 2 diabetes (T2D) and might
contribute to its pathogenesis either directly or through elevation of nonesterified fatty acids …

Acute metabolic and hormonal responses to the inhibition of lipolysis in non-obese patients with non-insulin-dependent (type 2) diabetes mellitus: effects of acipimox

GR Fulcher, M Walker, C Catalano, M Farrer… - Clinical …, 1992 - portlandpress.com
1. Increased rates of fatty acid oxidation are frequently observed in patients with non-insulin-
dependent diabetes mellitus and may contribute to hyperglycaemia by both decreasing …

[HTML][HTML] Control of fatty acid and glycerol release in adipose tissue lipolysis

D Langin - Comptes rendus biologies, 2006 - Elsevier
Adipose tissue lipolysis is the catabolic process leading to the breakdown of triglycerides
stored in fat cells and the release of fatty acids and glycerol. Recent work has revealed that …

Suppression of whole body and regional lipolysis by insulin: effects of obesity and exercise

RC Hickner, SB Racette, EF Binder… - The Journal of …, 1999 - academic.oup.com
The aim of this study was to evaluate in premenopausal women (six endurance-trained
nonobese, six sedentary nonobese, and five sedentary obese) the suppression of whole …

Sustained endogenous glucose production, diminished lipolysis and non-esterified fatty acid appearance and oxidation in non-obese women at high risk of type 2 …

S Forbes, S Robinson, J Dungu… - European journal of …, 2006 - academic.oup.com
Objective To evaluate early defects in glucose production, lipolysis and fatty acid oxidation
in non-obese, normally glucose tolerant women, who are nevertheless at risk of type 2 …

Subcutaneous adipocyte lipolysis contributes to circulating lipid levels

M Rydén, P Arner - Arteriosclerosis, thrombosis, and vascular …, 2017 - Am Heart Assoc
Objective—Fatty acids released via fat cell lipolysis can affect circulating lipid levels.
However, the contribution of different lipolysis measures in adipose tissue is unknown and …

A novel use of the hyperinsulinemic-euglycemic clamp technique to estimate insulin sensitivity of systemic lipolysis

M Stumvoll, HG Wahl, K Löblein… - Hormone and …, 2001 - thieme-connect.com
In humans, lipolysis and the resulting release of free fatty acids (FFAs) and glycerol from
stored triglycerides is of fundamental metabolic importance [1]. Insulin is the most potent …

[HTML][HTML] Temporal patterns of lipolytic regulators in adipose tissue after acute growth hormone exposure in human subjects: A randomized controlled crossover trial

AJ Hjelholt, KY Lee, MC Arlien-Søborg… - Molecular …, 2019 - Elsevier
Objective Growth hormone (GH) stimulates lipolysis, but the underlying mechanisms remain
incompletely understood. We examined the effect of GH on the expression of lipolytic …

Impaired adipose tissue lipid storage, but not altered lipolysis, contributes to elevated levels of NEFA in type 2 diabetes. Degree of hyperglycemia and adiposity are …

MJ Pereira, S Skrtic, P Katsogiannos, N Abrahamsson… - Metabolism, 2016 - Elsevier
Background Elevated levels of circulating non-esterified fatty acids (NEFA) mediate many
adverse metabolic effects. In this work we aim to determine the impact of type 2 diabetes …