Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome
characterized by impaired speech development and linguistic deficits. Recent genomic …

Half the members of the KE family suffer from a speech and language disorder caused by a
mutation in the FOXP2 gene. We examined functional brain abnormalities associated with …

Abstract Language is a uniquely human trait likely to have been a prerequisite for the
development of human culture. The ability to develop articulate speech relies on …

Cognitive and motor deficits associated with language and speech are seen in humans
harboring FOXP2 mutations. The neural bases for FOXP2 mutation-related deficits are …

Fundamental human traits, such as language and bipedalism, are associated with a range
of anatomical adaptations in craniofacial shaping and skeletal remodeling. However, it is …

Human speech and language are among the most complex motor and cognitive abilities.
The discovery of a mutation in the transcription factor FOXP2 in KE family members with …

Disruptions of the FOXP2 gene cause a speech and language disorder involving difficulties
in sequencing orofacial movements. FOXP2 is expressed in cortico-striatal and cortico …

Childhood syndromes disturbing language development are common and display high
degrees of heritability. In most cases, the underlying genetic architecture is likely to be …

Foxp2 and Foxp1 are recently identified members of the Fox family of winged‐helix/forkhead
transcription factor genes. A recent study has found that mutations in human FOXP2 produce …

Using a mouse model, Enard et al.(2009) show that the human form of the FOXP2 gene
increases synaptic plasticity and dendrite connectivity in the basal ganglia. These results …