Background: We examined the potential of metformin (MET) to enhance non-small cell lung
cancer (NSCLC) responses to ionising radiation (IR). Methods: Human NSCLC cells, mouse …

The anti-cancer effects of metformin, the most widely used drug for type 2 diabetes, alone or
in combination with ionizing radiation were studied with MCF-7 human breast cancer cells …

Over the last decade, evidence has emerged to support a role for the antidiabetic drug
metformin in the prevention and treatment of cancer. In particular, recent studies …

Pancreatic cancer is relatively radioresistant, however, radiotherapy has been shown to
provide efficacy in the treatment of local disease. To increase the effectiveness of …

Esophageal squamous cell carcinomas (ESCC) have become a severe threat to health and
the current treatments for ESCC are frequently not effective. Recent epidemiological studies …

Activation of the mammalian target of rapamycin (mTOR) pathway is an important and early
event in tobacco carcinogen–induced lung tumorigenesis, and therapies that target mTOR …

Metformin is a widely used drug in today's prescriptions by physicians due to its specific
effects in treating and curing type II diabetes. Diabetes is a common disease that may occur …

Metformin is the most commonly prescribed drug for type II diabetes and is associated with
decreased cancer risk. Previously, we showed that metformin prevented tobacco carcinogen …

Cancer cells display enhanced growth rates and a resistance to apoptosis. The ability of
cancer cells to evade homeostasis and proliferate uncontrollably while avoiding …

Purpose: Metformin is a widely used antidiabetic drug whose anticancer effects, mediated by
the activation of AMP-activated protein kinase (AMPK) and reduction of mTOR signaling …