The birth of a deadly yeast: tracing the evolutionary emergence of virulence traits in Candida glabrata

T Gabaldón, L Carreté - FEMS yeast research, 2016 - academic.oup.com
The yeast Candida glabrata is an opportunistic human fungal pathogen whose incidence
has increased in the last two decades. Despite its name, this yeast is only distantly related to …

[HTML][HTML] From Jekyll to Hyde: The Yeast–Hyphal Transition of Candida albicans

EWL Chow, LM Pang, Y Wang - Pathogens, 2021 - mdpi.com
Candida albicans is a major fungal pathogen of humans, accounting for 15% of nosocomial
infections with an estimated attributable mortality of 47%. C. albicans is usually a benign …

[HTML][HTML] Comparative genomics of emerging pathogens in the Candida glabrata clade

T Gabaldón, T Martin, M Marcet-Houben, P Durrens… - BMC genomics, 2013 - Springer
Background Candida glabrata follows C. albicans as the second or third most prevalent
cause of candidemia worldwide. These two pathogenic yeasts are distantly related, C …

[HTML][HTML] Synergistic regulation of hyphal elongation by hypoxia, CO2, and nutrient conditions controls the virulence of Candida albicans

Y Lu, C Su, NV Solis, SG Filler, H Liu - Cell host & microbe, 2013 - cell.com
Candida albicans reversibly switches between yeast and hyphal morphologies, with hyphae
being associated with virulence. Hyphal initiation and maintenance depend on host …

Evolutionary genomics of yeast pathogens in the Saccharomycotina

T Gabaldón, MA Naranjo-Ortíz… - FEMS yeast …, 2016 - academic.oup.com
Saccharomycotina comprises a diverse group of yeasts that includes numerous species of
industrial or clinical relevance. Opportunistic pathogens within this clade are often assigned …

Candida survival strategies

M Polke, B Hube, ID Jacobsen - Advances in Applied Microbiology, 2015 - Elsevier
Only few Candida species, eg, Candida albicans, Candida glabrata, Candida dubliniensis,
and Candida parapsilosis, are successful colonizers of a human host. Under certain …

The metabolic basis of Candida albicans morphogenesis and quorum sensing

TL Han, RD Cannon, SG Villas-Bôas - Fungal Genetics and Biology, 2011 - Elsevier
Candida albicans is a polymorphic fungus that has the ability to rapidly switch between
yeast and filamentous forms. The morphological transition appears to be a critical virulence …

Genetically regulated filamentation contributes to Candida albicans virulence during corneal infection

BE Jackson, KR Wilhelmus, BM Mitchell - Microbial pathogenesis, 2007 - Elsevier
Candida albicans is a commensal fungus of the normal flora yet causes opportunistic
infection following trauma or surgery and during immunosuppression. C. albicans virulence …

[HTML][HTML] Transcriptional Circuits Regulating Developmental Processes in Candida albicans

DL Rodriguez, MM Quail, AD Hernday… - Frontiers in Cellular and …, 2020 - frontiersin.org
Candida albicans is a commensal member of the human microbiota that colonizes multiple
niches in the body including the skin, oral cavity, and gastrointestinal and genitourinary …

In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination

K Zakikhany, JR Naglik… - Cellular …, 2007 - Wiley Online Library
Candida albicans is the most common oral fungal pathogen of humans, but the mechanisms
by which C. albicans invades and persists within mucosal epithelium are not clear. To …