It is well known that chromatin structure is highly sensitive to the ionic environment.
However, the combined effects of a physiologically relevant mixed ionic environment of K+ …

ATP-dependent chromatin remodelling enzymes (remodellers) regulate DNA accessibility in
eukaryotic genomes. Many remodellers reposition (slide) nucleosomes, however, how DNA …

Nucleosomes play a dual role in compacting the genome and regulating the access to DNA.
To unravel the underlying mechanism, we study fluorescently labeled mononucleosomes by …

Intracellular membraneless organelles and their myriad cellular functions have garnered
tremendous recent interest. It is becoming well accepted that they form via liquid–liquid …

Nucleoli are multicomponent condensates defined by coexisting sub-phases. We identified
distinct intrinsically disordered regions (IDRs), including acidic (D/E) tracts and K-blocks …

Chromatin remodelers use a helicase-type ATPase motor to shift DNA around the histone
core. Although not directly reading out the DNA sequence, some chromatin remodelers …

Ribonucleoprotein (RNP) granules are membraneless organelles (MLOs), which majorly
consist of RNA and RNA-binding proteins and are formed via liquid–liquid phase separation …

The dynamics of chromatin provides the access to DNA within nucleosomes, and therefore,
this process is critically involved in the regulation of chromatin function. However, our …

Nucleosomes and chromatin control eukaryotic genome accessibility and thereby regulate
DNA processes, including transcription, replication, and repair. Conformational dynamics …

Mononucleosomes, the basic building blocks of chromatin, contain two copies of each core
histone. The associated posttranslational modifications regulate essential chromatin …